HealthBeat News

Category: Senior Health

  • A Great New Wellness Club Service For You!

    New – Brief Medical Consultations by Telephone.

    Get Fast, Professional Answers To Your Most Pressing Health Questions

    Do you need a few medical questions answered but don’t want or need a full patient consultation – complete with in-depth case study, research, and written recommendations – at this time?

    A Brief Phone Consultation with Dr. Myatt may be all you need to get your questions answered.

    Dr. Myatt is now available for brief telephone consultations. Each 15-minute increment costs only $40, and many people find that a single 15-minute session with Dr. Myatt is sufficient to get their most pressing questions answered.

    • Struggling to understand hormone balance?
    • Wrestling with weight loss and wondering about the benefits and risks of the different diets?
    • Want the straight scoop on cancer treatments?
    • Wondering what the latest research is on diabetes treatments and how it affects you?
    • Need to know the truth about cholesterol or blood pressure?
    • Want to hear an honest opinion of the latest "miracle" juice or vitamin or supplement?

    The answers to these questions and many more are just an inexpensive phone call away.

    Knowledge is power. Knowledge is also your key to good health. Don’t deprive yourself of valuable knowledge any longer!

    Please visit our website here: Brief Medical Consultations  for more information on how this great new service works for you and to book your Brief Medical Consultation now!

  • The Ugly Truth About "Bone-Building" Drugs for Osteoporosis

    The Ugly Truth About "Bone-Building" Drugs for Osteoporosis

    (And The Safe, Natural, Effective Alternative)

    By Dr. Dana Myatt

    Osteoporosis means "porous bone," a bone-thinning disease that affects some 25 million American women. It is called a "silent" disease because it comes on with few or no symptoms. Often, a fall resulting in a fracture is the first evidence of weakened bones. Other symptoms and signs of osteoporosis include a decrease in height, spontaneous hip or vertebrae fractures, and back pain. (Note: most back pain is NOT caused by osteoporosis, so don’t get hypochodriacal on me!)

    In elderly women, death resulting from complications of hip fracture is far more common than death from breast cancer, yet few people realize the potential seriousness of this condition. Although osteoporosis is more common in post-menopausal women, it also occurs in younger women, in men, and in all age groups. Caucasian and Asian women are at greatest risk because their bones tend to be less dense to begin with.

    OK, you get the picture. Osteoporosis is clearly a real health problem for many Americans. So it seems reasonable to take a medication that can make bones thicker if you’ve been told that you have osteopenia or osteoporosis, right? Please don’t go there until you consider these facts.

    The Drug Is A Success – The Bone Died. ("To Save The Village We Had To Burn It Down")

    The popular drugs prescribed for osteoporosis — alendronate (Fosamax, Fosamax Plus D), etidronate (Didronel), ibandronate (Boniva), pamidronate (Aredia), risedronate (Actonel, Actonel W/Calcium), tiludronate (Skelid), and zoledronic acid (Reclast, Zometa) — are all in a class of drugs called "bisphosphinates." (Abbreviated as "BP’s"). Although they are marketed as "bone-building" drugs, the real truth is quite a bit more ominous. These drugs work by killing a type of bone cell called osteoclasts. You read that right — the drug works by killing normal bone cells.

    But Wait! There’s More! ("Other Than That, Mrs. Lincoln, How Was The Play?")

    In addition to this insane "mechanism of action" (killing normal bone cells), the potential side-effects range from a mere nuisance to deadly serious.

    Stomach upset, inflammation and erosions of the esophagus are a common side-effect of the oral forms of these drugs. But not to worry that this might be a sign that the drug isn’t healthy for your body. Your doctor will simply tell you to "remain seated upright for 30 to 60 minutes after taking the medication." Wasn’t that easy? Problem solved.

    Bisphosphonates given by injection bypass the stomach troubles but have their own problems, including "flu-like symptoms after the first infusion." Manufacturers claim that this only happens the first time, but a quick search of online bulletin boards of people who have had this reaction tells a different story. Many people report severe flu-like symptoms and bone pain that was aggravated by each subsequent dose.

    One study found in increase in "serious atrial fibrillation" among zoledronic acid (Reclast, Zometa) users, but the FDA dismissed this as "not significant." Since all these drugs are in the same class, however, the finding raises concern about this atrial fib connection and ALL bisphosphonate drugs.

    [Nurse Mark Note: Atrial Fibrillation can quickly develop into a heart attack]

    Last and not least, bispohsphonate drugs (ALL of them) are associated with a osteonecrosis of the jaw. In plain English, this means death of the jaw bone. The problem occurs more often with IV BP’s but is also seen in oral BP use. As one medical article stated, "This complication can have a significant impact on the quality of life for those patients with advanced stages of necrosis." Uh, you mean because the dead part of the jawbone will have to be removed and possibly bone-grafted? With resultant facial deformity (not to mention pain and suffering)? Yeah, that might ruin your week… or month… or life…

    Is Bone Death Better Than Osteoporosis? (Is That Really A Serious Question?)

    Obviously, I’m not a fan of bisphosphonate drugs. The class of bone cells that they destroy — the osteoclasts — help to "remodel" bone. This means that bone is supposed to be a living, growing, constantly changing tissue. Bisphosphonates change all that.

    On the other hand, a life-threatening fracture from osteoporosis is no picnic, either. So what do I recommend for osteoporosis prevention and reversal? Nature’s way, of course!

    Rebuilding Bone The Natural Way

    It has long been known that declining sex hormones are associated with decreased bone mineralization. It is also known that un-natural hormone replacement, as practiced in conventional medicine, is a cause of breast and other hormone-related cancers (and increased risk of stroke, heart disease, blood clots and dementia).
    The "middle ground" on hormone replacement therapy is to use natural (bio-identical) hormone replacement therapy as practiced by holistic medical practitioners. Following hormone testing (urine testing is better than saliva or blood tests), a custom formula using doses and forms as found in nature will be prescribed.

    Normal bone formation requires the right "mix" of nutrients. Vitamin D is necessary for proper bone mineralization, and the latest medical research shows that we are getting far less than we really need. [NOTE: Maxi Multi’s have just been re-formulated to include 800IU instead of the previous 400IU per daily dose]. Folate, vitamin B6, B12 and vitamin K should also be in your daily "mix" and are found in optimal amounts in Maxi Multi’s.

    Exercise, especially the kind that puts some stress on bones such as walking, help "tell" the bones to take up more minerals.

    And of course, the minerals that build bone must be present. This usually requires mineral supplementation with calcium, magnesium, boron, manganese, zinc, copper and the "forgotten mineral," strontium.

    Strontium, the "Secret Sauce" for Strong Bones

    Strontium, a naturally-occurring mineral in the same class as calcium and magnesium, has been shown to prevent bone loss AND increase bone density even in already-established cases of osteoporosis. This, plus strontium (NOT the radioactive kind!) has little if any negative side effects. Read more about Strontium: The Missing Mineral for Osteoporosis Prevention and Reversal in this previous edition of HealthBeat.

    The Short Course On Strong Bones And Bone Remineralization

    Osteoporosis is not caused by a bisphosphonate deficiency! Given the potentially devastating side-effects of this class of drugs, doing it "nature’s way" should be a first choice for most people with osteoporosis (or those interested in prevention).

    Exercise, sex hormone balance and obtaining all necessary bone nutrients including strontium will prevent and reverse most cases of osteoporosis without causing harm in the process.
    References:

    References:
    1.) Osteoporosis: Part I. Evaluation and Assessment. American Family Physician, March 1, 2001.
    2.) Side effects courtesy of Merk’s Fosamax website: http://www.fosamax.com/alendronate_sodium/fosamax/consumer/side_effects/index.jsp
    3.) Ale
    ndronate and atrial fibrillation. N Engl J Med. 2007 May 3;356(18):1895-6
    4.) Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis.  N Engl J Med. 2007 May 3;356(18):1809-22
    5.) Osteonecrosis and bisphosphonates in oral and maxillofacial surgery. Oral Maxillofac Surg Clin North Am. 2007 May;19(2):199-206.
    6.) Biophosphonate-related osteonecrosis of the jaws. Dent Clin North Am. 2008 Jan;52(1):111-28.
    7.) Bisphosphonate Use and the Risk of Adverse Jaw Outcomes: A medical claims study of 714,217 people. J Am Dent Assoc. 2008 Jan;139(1):23-30.
    8.) Osteonecrosis of the jaws secondary to bisphosphonate therapy: a case series. J Contemp Dent Pract. 2008 Jan 1;9(1):63-9.
    9.) Bisphosphonate osteonecrosis of the jaws; an increasing problem for the dental practitioner. Br Dent J. 2007 Dec 8;203(11):641-4.
    10.) Bisphosphonates and bisphosphonate induced osteonecrosis. Oral Maxillofac Surg Clin North Am. 2007 Nov;19(4):487-98, v-vi.
    11.) The current state of postmenopausal hormone therapy: update for neurologists and epileptologists. Epilepsy Curr. 2007 Sep-Oct;7(5):119-22.
    12.) Strontium Ranelate Reduces the Risk of Nonvertebral Fractures in Postmenopausal Women with Osteoporosis: Treatment of Peripheral Osteoporosis (TROPOS) Study. J Clin Endocrinol Metab. 2005 May; 90(5):2816-22. Epub 2005 Feb 22.
    13.) Picking a bone with contemporary osteoporosis management: Nutrient strategies to enhance skeletal integrity. Clinical Nutrition (Epub ahead of print, 2006 October 12).
    14.) The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis.” New England Journal of Medicine 350 (2004):459 – 68.
    15.) Strontium ranelate reduces the risk of nonvertebral fractures in postmenopausal women with osteoporosis: Treatment of Peripheral Osteoporosis (TROPOS) study. Journal of Clinical Endocrinology and Metabolism 90 (2005):2816 – 22.
    16.) Strontium in Finnish foods. International Journal for Vitamin and Nutrition Research 52 (1982): 342 – 50.
    17.) Gaby AR. Preventing and Reversing Osteoporosis. Rocklin, CA: Prima Publishing, 1994, 85–92 [review].
    18.) Strontium ranelate: a dual mode of action rebalancing bone turnover in favour of bone formation. Curr Opin Rheumatol. 2006 Jun;18 Suppl 1:S11-5.

  • Gallbladder "Attacks" and Gallstones

    How to End the Pain and Save Your Gallbladder

    Nearly half a million gallbladder surgeries — removal, or cholecystectomy to be precise — are performed each year in the US. Many of the people who give up their gallbladders to such surgery appear to be fine, and the pain of their gallbladder attacks are over. Oddly enough, for many others, gallbladder "attacks" continue even in the absence of a gallbladder – in fact, one authoritative source indicates that Post Cholecystectomy Syndrome (PCS) affects at least 10 to 15% of people who have had their gallbladders removed!

    Are the people who have given up their gallbladders really "fine"? And why do others continue to have pain in spite of removal of their gallbladder? What is the real cause of Gallbladder pain? And most importantly, what can be done about it?

    You may be surprised at the answers to these questions – Dr. Myatt has written an informative and fully-referenced article that could just save you from needless surgery and from the pain and suffering of gallbladder disease. Check it out here at The Wellness Club website!

  • What’s Burning You?

    What’s Burning You?

    The REAL Cause of Heartburn, Indigestion and GERD (and How To Correct It)

    By Dr. Dana Myatt

    Older people have considerably more digestive problems than younger folks, and this has typically but incorrectly been blamed on over-production of stomach acid. Not only have medical studies debunked excess stomach acid as the cause of indigestion, but common sense debunks the myth as well.

    Why does this matter? Because the chronic use of antacids and acid-blocking drugs for indigestion has some dangerous and even deadly side-effects

    The "Acid Over-Production" Myth Debunked

    Do you really think that some bodily function starts working better with age? Hahahaha!

    With age, nothing works as well as it did in earlier years. I hope I’m not popping anyone’s bubble here.

    Come on – we don’t move as fast at age 57 as we did at 27. Vision and hearing are typically less acute in our 70s than they were in our 30s. Skin is less elastic at 69 than at 29. Production of hormones and body fluids decreases with age. Why would we think that our stomachs do the opposite of all other organs and become more active with age instead of less active? Only a drug salesman or a pill-pushing doctor would try to convince us of such foolishness.

    The stomach’s primary job is to digest protein and emulsify fats, and it does this by making an extremely powerful acid called hydrochloric acid (HCL) and a protein-digesting enzyme called pepsin. The hydrochloric acid made by a healthy stomach is one million times stronger than the mild acidity of urine or saliva. A leather-like strip of jerky can be quickly turned into "beef soup" by the action of hydrochloric acid and pepsin in the stomach. That’s how normal digestion is supposed to work.

    But just like the rest of an aging body, the stomach’s hydrochloric acid and pepsin production decreases over time. As a result, we do not digest food as well. The term "indigestion" implies lack of digestion, not over-digestion. This is why we can’t eat a whole pepperoni pizza washed down with a bottle of soda like we did when we were teenagers. Our aging stomachs don’t have the same digestive vigor – strong hydrochloric acid and pepsin – to digest food like youthful stomachs do.

    Medical Science Verifies Low Acid Production

    OK, that’s the common sense of it. Now here’s the science. Many older studies conducted on several thousand people in the 1930’s and 1940’s showed that half of all people by age 60 were functioning at only 50% gastric acid output. Numerous contemporary studies verify that that stomach acid production often declines with age.
    The Bottom Line: when someone over age 40 has chronic or chronic / intermittent indigestion, that indigestion is almost certainly due to a weaker stomach with less acid and pepsin output, not a stronger stomach making more digestive juices.

    "But My Symptoms Feel Like Too Much Acid…"

    Strong stomach acid and pepsin quickly "emulsify" fats and proteins, making them ready for the next step of digestion, passage into the small intestine. When these digestive factors are weak, food remains in the stomach for longer and it begins to ferment. Gas pressure from the fermentation can cause bloating and discomfort and can can also cause the esophageal sphincter to open, allowing stomach contents to "backwash" into the esophagus.

    Even though weak stomach acid is the central cause of this, even this weak stomach acid, which has no place in the esophagus, will "burn." This burning sensation confuses many people, including doctors, who then "ASSuME" that excess acid is to blame. Too little acid, resulting in slowed digestion, and gas which creates back-pressure into the esophagus is the real cause of almost all "heartburn" and GERD.

    Why People Take Acid-Blockers

    Why in the world would anyone take antacids or acid blockers to correct a deficiency of stomach acid? In two words: symptom relief.

    But if heartburn or gastro esophageal reflux disease (GERD) are caused by too little stomach acid, why does blocking more of the acid relieve the discomfort? And why isn’t that a good thing to do?

    Remember, even weak stomach acid does not belong in the esophagus. When ALL acid production is blocked, the “backwash” of stomach contents into the esophagus will not burn. However, repeatedly using this “band-aid” method has some serious long-term consequences.

    The Dangers of Antacids and Acid-Blocking Drugs

    Our bodies need 60 or so essential nutrients. “Essential” means that the body MUST have this nutrient or death will eventually ensue, and the nutrient must be obtained from diet because the body cannot manufacture it. Many of these essential nutrients require stomach acid for their assimilation. When stomach acid production declines, nutrient deficiencies begin.

    Calcium, for example, requires vigorous stomach acid in order to be assimilated. Interestingly, the rate of hip replacement surgery is much higher in people who routinely use antacids and acid-blocking drugs. We know that people who have “acid stomach” were already having trouble assimilating calcium from food and nutritional supplements due to lack of normal stomach acid production. When these symptoms are “band-aided” with drugs which decrease stomach acid even more, calcium assimilation can come to a near-halt. The result? Weak bones, hip fractures and joint complaints resulting in major surgery.

    Jonathan Wright, M.D., well-known and respected holistic physician, states that “Although research in this area is entirely inadequate, its been my clinical observation that calcium, magnesium, iron, zinc, copper, chromium, selenium, manganese, vanadium, molybdenum, cobalt, and many other micro-trace elements are not nearly as well-absorbed in those with poor stomach acid as they are in those whose acid levels are normal. When we test plasma amino acid levels for those with poor stomach function, we frequently find lower than usual levels of one or more of the eight essential amino acids: isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, and valine. Often there are functional insufficiencies of folic acid and/or vitamin B12.”

    Remember, these are essential nutrients. Deficiencies of any single one of them can cause serious health problems over time. Weak bones, diminish immune function, failing memory, loss of eyesight and many other “diseases of aging” are often the result of decreased stomach function.

    Ulcers can even be caused by too little acid. Surprised? We know today that most ulcers are caused by a bacterium called h. pylori. This little beastie is killed by strong stomach acid. But when stomach acid is weak, watch out! Weak stomach acid is how h. pylori gets a foot-hold. (People with active ulcers should not supplement hydrochloric acid until the ulcer has healed).

    Diseases Associated with Low Gastric Function

    Low stomach acid is associated with the following conditions:

    • Acne rosacea
    • Addison’s disease
    • Allergic reactions
    • Candidiasis (chronic)
    • Cardiac arrhythmias
    • Celiac disease
    • Childhood asthma
    • Chronic autoimmune hepatitis
    • Chronic cough
    • Dermatitis herpeteformis
    • Diabetes (type I)
    • Eczema
    • Gallbladder disease
    • GERD
    • Graves disease (hyperthyroid)
    • Iron deficiency anemia
    • Laryngitis (chronic)
    • Lupus erythromatosis
    • Macular degeneration
    • Multiple sclerosis
    • Muscle Cramps
    • Myasthenia gravis
    • Mycobacterium avium complex (MAC)
    • Osteoporosis
    • Pernicious anemia
    • Polymyalgia rheumatica
    • Reynaud’s syndrome
    • Rheumatoid arthritis
    • Scleroderma
    • Sjogren’s syndrome
    • Stomach cancer
    • Ulcerative colitis
    • Vitiligo

    It also appears that many cases of depression, which appear related to too little neurotransmitters (which in turn are made from amino acids) may in fact be inability to absorb the necessary precursors due to – you guessed it – low stomach acid. I suspect there are a large number of other diseases that begin with a failing digestive system and that have not yet been recognized as such.

    Even so, many people who have low stomach acid do not have symptoms of heartburn, “acid indigestion” or GERD.

    The Gastric Acid Function Test

    Here’s a simple question. Before your doctor diagnosed GERD from “too much stomach acid,” did he/she perform a stomach acid function test?

    X-rays and gastroscopy do not evaluate stomach acid production. The medical test for stomach acid, called the Heidelberg test, requires swallowing a small capsule and then having it pulled back up on a “string.” You’d remember if you had this done. Interestingly, this test is ALMOST NEVER PERFORMED before excess stomach acid is diagnosed, hence the incorrect diagnosis!

    Why The Blind Spot In Medicine?

    From the 1800’s up until the 1950’s, hydrochloric acid (HCl) supplements (both with and without pepsin) were widely prescribed and used. Physicians simply considered replacement of digestive acid to be like replacement of thyroid hormone for a failing thyroid or hormone replacement for aging ovaries.

    In the 1950’s, some badly designed and misinterpreted “research” was used to convince physicians that HCl and pepsin replacement therapy is unnecessary. Besides, the “replacement” therapy – HCL and pepsin – are natural substances that are difficult to patent. Instead, drug companies focused on patentable drugs to treat “hyperchlorhydria” (excess stomach acid), and the highly profitable prescription and OTC acid blocking drug industry was born.

    Once again I ask: if a doctor diagnosed you with excess stomach acid, did he or she actually perform the Heidelberg test? If you diagnosed yourself, did you perform a gastric acid self-test? No? I rest my case.

    The Gastric Acid Function Self-Test

    Fortunately, the Heidelberg test is not required to arrive at a correct diagnosis of too little stomach acid. You can perform a gastric acid self-test at home using some betain HCL capsules taken with meals. If digestion improves – bingo! You’re hydrochloric acid deficient.

    This issue of low stomach acid is central to so many diseases that I recommend a gastric acid self-test to EVERYONE over age 50 and anyone under age 50 who has any medical complaint related to nutrient deficiency.

    I’ve put together an inexpensive yet highly effective “Gastric Acid Function Self Test Kit” that includes full instructions for testing your own stomach acid (it’s easy with the instructions) plus “test sizes” of the supplements – including hydrochloric acid and pepsin – needed for the test.

    Testing your own digestive function is simple and easy, and it could save you much grief, sickness, and yes, heartburn.

    References
    1.) Gastric observations in achlorhydria. J Dig Dis. 1941, 8: 401-407.
    2.) Gastrointestinal Tract Disorders in the Elderly, pp. 62-69. Edinburgh: Churchill Livingstone: 1984.
    3.) Age related changes in gut physiology and nutritional status. Gut. 1996 Mar; 38(3):306-9.
    4.) A retrospective study of the usefulness of acid secretory testing.  Aliment Pharmacol Ther. 2000 Jan;14(1):103-11.
    5.) Age related changes in gut physiology and nutritional status. Gut. 1996 Mar;38(3):306-9.
    6.) Hypochlorhydria: a factor in nutrition. Annu Rev Nutr.  1989;9:271-85.
    7.) Gastric hypochlorhydria and achlorhydria in older adults. JAMA. 1997  Nov 26;278(20):1659-60.
    8.) The aging gut. Nutritional issues. Int J Nurs Pract. 2006  Apr;12(2):110-8. Summary: Aging is associated with decreased gastric  output.
    9.) The aging gut. Nutritional issues. Gastroenterol Clin North Am. 1998  Jun;27(2):309-24.
    10.) Changes in gastrointestinal function attributed to aging. Am J Clin  Nutr. 1992 Jun;55(6 Suppl):1203S-1207S.
    11.) Digestive function and aging. Hum Nutr Clin Nutr. 1983  Mar;37(2):75-89.
    12.) Symptomatic gastro-oesophageal reflux in a patient with achlorhydria. Gut. 2006 Jul;55(7):1054-5.
    13.) Effects of aging process on digestive functions. Compr Ther. 1991  Aug;17(8):46-52.
    14.) Fundic atrophic gastritis in an elderly population. Effect on hemoglobin and several serum nutritional indicators. J Am Geriatr Soc. 1986 Nov;34(11):800-6.
    15.) Vitamin B12 (cobalamin) deficiency in elderly patients. CMAJ. 2004  Aug 3;171(3):251-9.
    16.) Anemia caused by vitamin B 12 deficiency in subjects aged over 75  years: new hypotheses. A study of 20 cases. Rev Med Interne. 2000  Nov;21(11):946-54.
    17.) Cobalamin, the stomach, and aging. Am J Clin Nutr. 1997  Oct;66(4):750-9.
    18.) Age-related changes in cobalamin (vitamin B12) handling. Implications for therapy. Drugs Aging. 1998 Apr;12(4):277-92.
    19.) Intestinal malabsorption in the elderly. Digestive Diseases.  2007;25(2):144-50.
    20.) Gastric acid secretion in chronic iron-deficiency anaemia. Lancet.  1966 Jul 23;2(7456):190-2.
    21.) Involvement of the corporal mucosa and related changes in gastric acid secretion characterize patients with iron deficiency anaemia associated with Helicobacter pylori infection. Aliment Pharmacol Ther. 2001 Nov;15(11):1753-61.
    22.) The aging process as a modifier of metabolism. Am J Clin Nutr. 2000  Aug;72(2 Suppl):529S-32S.
    23.) Low gastric hydrochloric acid secretion and mineral bioavailability. Adv Exp Med Biol. 1989;249:173-84.
    24.) Effects of pH on mineral-phytate, protein-mineral-phytate, and  mineral-fiber interactions. Possible consequences of atrophic  gastritis on mineral bioavailability from high-fiber foods. J Am Coll  Nutr. 1988 Dec;7(6):499-508.
    25.) Long-term proton pump inhibitor therapy and risk of hip fracture.  JAMA. 2006 Dec 27;296(24):2947-53.
    26.) Antral atrophy, Helicobacter pylori colonization, and gastric pH. Am  J Clin Pathol. 1996 Jan;105(1):96-101.
    27.) High acid secretion may protect the gastric mucosa from injury caused by ammonia produced by Helicobacter pylori in duodenal ulcer patients. J Gastroenterol Hepatol. 1996 Jul;11(7):674-80.
    28.) Rosacea keratitis and conditions with vascularization of the cornea treated with riboflavin. Arch Ophthamol 1940;23:899–907.
    29.) Incidence of anti-Helicobacter pylori and anti-CagA antibodies in rosacea patients. Int J Dermatol. 2003 Aug;42(8):601-4.30.) Gastrointestinal findings in atopic children. Eur J Pediatr 1980;134:249–54.
    31.) Suppression of gastric H2-receptor mediated function in patients with bronchial asthma and ragweed allergy.
    Chest 1986;89:491–6.
    32.) Allison JR. The relation of hydrochloric acid and vitamin B complex deficiency in certain sk
    in diseases. South Med J 1945;38:235–41.
    33.) Effect of hydrochloric acid on iron absorption. N Engl J Med 1968;279:672–4.
    34.) The importance of gastric hydrochloric acid in the absorption of nonheme food iron. J Lab Clin Med 1978;92:108–16.
    35.) Bray GW. The hypochlorhydria of asthma in childhood. Q J Med 1931;24:181–97.
    36.) Candida overgrowth in gastric juice of peptic ulcer subjects on short- and long-term treatment with H2-receptor antagonists. Digestion.1983;28:158–63.
    37.) Antibacterial activity of the pancreatic fluid. Gastroenterology 1985;88:927–32 [review].
    38.) Non-immunological defense mechanisms of the gut. Gut 1990;33:1331–7 [review].
    39.) Characterization of gastric mucosal lesions in patients with celiac disease: a prospective controlled study.Am J Gastroenterol. 1999 May;94(5):1313-9.
    40.) Chronic cough due to gastroesophageal reflux disease: failure to resolve despite total/near-total elimination of esophageal acid. Chest. 2002 Apr;121(4):1132-40.
    41.) Gastric lesion in dermatitis herpetiformis.Gut.1976 Mar;17(3):185-8.
    42.) Auto-immune atrophic gastritis in patient with dermatitis herpetiformis. Acta Derm Venereol. 1976;56(2):111-3.
    43.) Predictive value of gastric parietal cell autoantibodies as a marker for gastric and hematologic abnormalities associated with insulin-dependent diabetes. Diabetes. 1982 Dec;31(12):1051-5.
    44.) Parietal cell antibodies and gastric secretion in children with diabetes mellitus. Acta Paediatr Scand. 1980 Jul;69(4):485-9.
    45.) Oesophageal acid exposure and altered neurocardiac function in patients with GERD and idiopathic cardiac dysrhythmias. Aliment  Pharmacol Ther. 2006 Jul 15;24(2):361-70.
    46.) Capper WM, Butler TJ, Kilby JO, Gibson MJ. Gallstones, gastric secretion and flatulent dyspepsia. Lancet 1967;i:413–5.
    47.) Gastric juice nitrite and vitamin C in patients with gastric cancer and atrophic gastritis: is low acidity solely responsible for cancer  risk? Eur J Gastroenterol Hepatol. 2003 Sep;15(9):987-93.
    48.) Correlation of ratio of serum pepsinogen I and II with prevalence of gastric cancer and adenoma in Japanese subjects. Am J Gastroenterol. 1998 Jul;93(7):1090-6.
    49.) Atrophic body gastritis in patients with autoimmune thyroid disease: an underdiagnosed association. Arch Intern Med. 1999 Aug 9-23;159(15):1726-30.
    50.) Early manifestations of gastric autoimmunity in patients with juvenile autoimmune thyroid diseases.J Clin Endocrinol Metab. 2004 Oct;89(10):4944-8.
    51.) Review article: the role of pH monitoring in extraoesophageal  gastro-oesophageal reflux disease. Aliment Pharmacol Ther. 2006  Mar; 23 Suppl 1:40-9. Summary: association with laryngitis, non-cardiac chest pain, etc.
    52.) Age-Related Eye Disease Study Group. Risk factors associated with age-related macular degeneration. Opthamology.
    53.) Altered gastric acidity in patients with multiple sclerosis. Cesk  Gastroenterol Vyz. 1968 Dec;22(8):526-30.
    54.) Gastroesophageal reflux disease, acid suppression, and Mycobacterium avium complex pulmonary disease. Chest. 2007 Apr;131(4):1166-72.
    55.) Malabsorption of vitamin B12 in dermatitis herpetiformis and its association with pernicious anaemia. Acta Med Scand. 1986;220(3):261-8
    56.) Small intestinal bacterial overgrowth in patients with rheumatoid arthritis. Ann Rheum Dis. 1993 Jul;52(7):503-10.
    57.) Hartung EF, Steinbroker O. Gastric acidity in chronic arthritis. Ann Intern Med 1935;9:252.
    58.) Hypochlorhydria and hypergastrinaemia in rheumatoid arthritis. Ann Rheum Dis. 1979 Feb;38(1):14-7
    59.) Francis HW. Achlorhydria as an etiological factor in vitiligo, with report of four cases. Nebraska State Med J 1931;16(1):25–6.

  • 7 Good Reasons To Take Take Grape Seed Extract

    7 Good Reasons To Take Take Grape Seed Extract

    by Dr. Dana Myatt

    Grape seed extract is on my list of "must take" supplements." Here’s why.

    Grape Seed Extract Lowers Risk of Heart Disease

    Proanthocyanidin (OPC), a powerful antioxidant found in grape seeds, grape skins, strawberries and French maritime pine bark, has anti-inflammatory properties which have been shown to promote normal blood flow and thus benefit the cardiovascular system. In Doctor Myatt’s words, OPC’s prevent "blood sludge" that can cause strokes and heart attacks. OPC’s work like aspirin (only better and safer) to prevent abnormal blood clotting. OPC’s may be a superior answer for those who need thinner blood (like people with arrhythmias) as a safer alternative to coumadin. OPC’s are also called "pycnogenol" when they are derived from pine bark (the grape seed extract is slightly more potent and less expensive. You will see the terms pycnogenol, OPC’s, grape seed extract used interchangeably).

    In one study, 38 cigarette smokers were divided into two groups and received either 500 mg of aspirin or 125 mg of Pycnogenol. After taking these doses, each subject smoked a cigarette, which is known to increase blood platelet aggregation (blood clumping). After two hours, blood samples were analyzed. Both groups has greatly reduced platelet aggregation, but those in the aspirin group had increased bleeding times while those in the OPC group did not. Other studies in smokers have also shown the anti-aggregation effect of OPC’s.

    In another study, 30 people were given Pycnogenol and 10 were given placebo. People in the Pycnogenol group had significant reduction in blood pressure, capillary (small blood vessel) leakage, and blood vessel inflammation, all risk factors for heart disease. There were no negative side effects or adverse changes in blood chemistries from pycnogenol.

    Grape Seed Extract A Boon to Diabetics
    (and those who don’t want to be diabetics)

    Pycnogenol benefits the cardiovascular system by decreasing inflammation and improving blood viscosity in both normal and diabetic subjects. These effects can be especially important to diabetics. New research shows that OPC’s have even more benefits for diabetics by helping to lower blood sugar levels and improving microcirculation.

    OPC’s were administered to diabetic patients. Leg ulcers (which often result in gangrene and loss of limbs in diabetics) healed 25-29% faster in the group taking OPC’s. This is a significant benefit for diabetic patients and could help prevent loss of limbs that often occurs in diabetes.

    OPC’s have also been shown to help lower blood sugar levels. Researchers looked at the effect that Pycnogenol on alpha-glucosidase, an enzyme that breaks down carbohydrates into glucose molecules. In this study, pycnogenol was compared to acarbose, a synthetic drug (sold under the brand name Precose) that inhibits alpha-glucosidase. Pycnogenol was found to be 190 times more potent at inhibiting alpha-glucosidase, producing a greater delay in glucose absorption. At higher concentrations, OPC’s greatly slowed the entrance of carbohydrates into the blood stream compared to the drug.

    Another study showed that pycnogenol improved the level of microangiopathy (small blood vessel abnormalities) decreased capillary filtration, improved symptoms and reduced edema in 18 out of 18 diabetic patients, with no subjects dropping out of the study due to adverse side effects. There were no improvements seen in the control group.

    OPC’s have been shown in French trials to help limit the progression of diabetic retinopathy. In one study, 60% of diabetics taking 150 mg per day of OPCs from grape seed extract had no progression of retinopathy compared to 47% of those taking a placebo.

    Another trial including 77 subjects with type 2 diabetes, (half receiving 100 mg of Pycnogenol and half received a placebo daily), showed after 12 weeks that subjects in the Pycnogenol group had significantly lowered their plasma glucose levels compared to placebo. Pycnogenol subjects were also found to have improved artery function. In another trial of 30 type 2 diabetics, researchers found that increasing doses of pycnogenol (doses of 50, 100, 200, and 300 mg) lowered blood sugar levels in a dose-dependent fashion. (The more grape seed extract, the lower the blood sugar levels). Subjects who received 100 to 300 mg of Pycnogenol had the most significant lowering of their fasting glucose levels.

    Anti-Cancer Effects of Grape Seed Extract

    Talc (talcum powder) increases "ovarian neoplastic transformation" (turns cells of the female ovary into cancerous cells). A brand new study showed that pycnogenol blocked this talc-induced cancerous change in ovarian cells. PC’s have also been shown to induce apoptosis (programmed cell death) in breast cancer cells but not in normal breast tissue.

    OPc’s reduce four factors know to stimulate cancer cell growth: blood sugar levels, insulin levels, free radical and inflammation. This means that OPC’s may be a potent factor not only in cancer prevention but also in cancer treatment. (See our medical paper on cancer diet and nutrition for cancer for full details).

    But Wait! There’s More! (More Benefits of Grape Seed Extract)

    If heart-protective, anti-diabetic, anti-cancer effects aren’t enough to make you consider adding grape seed extract to your supplement regimen, here are a few more benefits of this amazing flavonoid for you to consider:

    * anti-allergenic (grape seed stabilizes histamine release and so acts as a natural anti-histamine, without any drowsy side-effects). Asthmatic children who took pycnogenol were able to decrease their asthma medications.

    * improves skin elasticity by increasing collagen in the skin. For this reason, OPC’s are often used in skin rejuvenation programs.

    * prevents varicose veins by strengthening blood vessels and increasing collagen (same reason it helps improve aging skin).

    * helps prevent Alzheimer’s disease by blocking the formation of beta amyloid (a protein associated with Alzheimer’s).

    * Reduces symptoms of endometriosis. This was recently reported in Family Medicine journal; yet another study showing positive benefit.

    I Don’t Know About You, But…

    The proven (but non-FDA-approved, blessed or verified) effects of grape seed extract (aka pycnogenol, OPC’s etc.) are just too great for me to overlook. I personally take 100mg, 3 times per day with meals and will continue to do so. The new research coming out on this important herb convinces me that I’ve made a good decision. Learn more about Grape Seed Extract here.

    References
    1.)Inhibition of smoking-induced platelet aggregation by aspirin and pycnogenol. Thromb Res. 1999 Aug 15;95(4):155-61.
    2.) Pine bark extract reduces platelet aggregation. Integr Med. 2000 Mar 21;2(2):73-77.
    3.) Single and multiple dose pharmacokinetics of maritime pine bark extract (pycnogenol) after oral administration to healthy volunteers. BMC Clin Pharmacol. 2006 Aug 3;6:4.
    4.) Inhibition of COX-1 and COX-2 activity by plasma of human volunteers after ingestion of French maritime pine bark extract (Pycnogenol). Biomed Pharmacother. 2006 Jan;60(1):5-9. Epub 2005 Oct 26.
    5.) Diabetic ulcers: microcirculatory improvement and faster healing with pycnogenol. Clin Appl Thromb Hemost. 2006 Jul;12(3):318-23.
    6.) Oligomeric procyanidins of French maritime pine bark extract (Pycnogenol) effective
    ly inhibit alpha-glucosidase. Diabetes Res Clin Pract. 2006 Nov 10.
    7.) Rapid relief of signs/symptoms in chronic venous microangiopathy with pycnogenol: a prospective, controlled study. Angiology. 2006 Oct-Nov;57(5):569-76.
    8.) Procyanidolic oligomers in the treatment of fragile capillaries and diabetic retinopathy. Med Int 1981;16:432–4 [in French].
    8.) Retinopathies and OPC. Bordeaux Medicale 1978;11:1467–74 [in French].
    9.) Contribution to the study of procyanidolic oligomeres: Endotelon in diabetic retinopathy (in regard to 30 observations). Gaz Med de France 1982;89:3610–4 [in French].
    10.) Antidiabetic effect of Pycnogenol French maritime pine bark extract in patients with diabetes type II. Life Sci. 2004 Oct 8;75(21):2505-13.
    11.) French maritime pine bark extract Pycnogenol dose-dependently lowers glucose in type 2 diabetic patients.Diabetes Care. 2004 Mar;27(3):839.
    12.) Pycnogenol reduces talc-induced neoplastic transformation in human ovarian cell cultures.Phytother Res. 2007 Mar 14; [Epub ahead of print]
    13.) Selective induction of apoptosis in human mammary cancer cells (MCF-7) by pycnogenol. Anticancer Res. 2000 Jul-Aug;20(4):2417-20.
    14.) Nutritional and Botanical Considerations in the Systemic Treatment of Cancer: 2006 Update.     http://www.drmyattswellnessclub.com/cancer2006update.htm
    15.) Pycnogenol as an adjunct in the management of childhood asthma. J Asthma. 2004;41(8):825-32
    16.) Stabilization of collagen by polyphenols. Angiologica 1972;9:248–56 [in German].
    17.) Non-enzymatic degradation of acid-soluble calf skin collagen by superoxide ion: protective effect of flavonoids. Biochem Pharmacol 1983;32:53–8.
    18.) Pycnogenol protects neurons from amyloid-beta peptide-induced apoptosis. Brain Res Mol Brain Res. 2002 Jul 15;104(1):55-65.
    19.) Pine Bark Extract Reduces Symptoms of Endometriosis. J Reprod Med. 2007;52:000-000.