Category: Heart and Circulation

  • Danger! L-Carnitine Causes Heart Disease!

    That’s What The Headline Said, So It Must Be True – Right?

     

    By Nurse mark

     

    Our recently featured supplement ALA / ALC caught the attention of our eagle-eyed readers, who also have the memory attributed to elephants – who never forget.

    We received a few “heads-ups” and questions about a news article that made the rounds a few years ago, reporting on a study from the Cleveland Clinic.

    The article, written by a very prolific freelance writer by the name of Cari Nierenberg goes to great lengths to stress the evils of eating red meat (which contains carnitine) and concludes with this ominous warning:

    Pass it on: A compound called carnitine found in in red meat and supplements may increase the risk of heart disease.

    Yikes! This is scare-tactics journalism at its worst – just like my title for this article. But it worked, because Cari’s article was picked up (read: purchased) by dozens of different outlets from The Huffington Post to LiveScience.com and more. It also has taken on a life of its own on the internet, and is being reproduced and quoted in endless emails and blogs, all dedicated to warning us poor unwary and uneducated folk about the dangers of meat…

    I’m not going to rebut Cari’s article – it is a sensationalized but moderately accurate report of a very limited study done by the Cleveland Clinic that looked at the gut bacteria of people who ate red meat and found that in some of those people carnitine (and l-carnitine) could be broken down into a compound called trimethylamine-N-oxide (TMAO). The researchers then pointed to very preliminary and unproven research that suggested that TMAO might be bad for the heart. They then wrapped up this grand study of 10 subjects by concluding that meat eaters had gut bacteria that took carnitine and created TMAO which caused heart disease.

    I wonder if the researchers were a little out-of-breath after jumping to all those conclusions…

    I won’t try to rebut the research article or its conclusions either, since I would not be able to do any better than the doctors and research staff at Life Extension Foundation who produced a very thorough, well-researched, and quite readable rebuttal to the study in this article of August 2013:

    Rebuttal to Attack Against Carnitine
    By William Faloon, Steven V. Joyal, MD, Luke Huber, ND, MBA, Blake Gossard, and Richard A. Stein, MD, PHD

    The L.E.F. Report concludes:

    In the wake of a single negative study, deceptive media headlines have generated concern that supplemental forms of L-carnitine may be detrimental to heart health. This notion flies in the face of numerous published, peer-reviewed studies showing L-carnitine promotes cardiovascular health in a variety of ways. The media’s effort to generate outrageous headlines has undermined decades of scientific research on the heart-health benefits of carnitine.

    Carnitine is a vital nutrient for health. The discovery of carnitine’s ability to maximize cellular fuel efficiency and minimize the impact of normal cellular metabolism on delicate cellular machinery has led to a revolution in the way scientists think about some of the most troubling age-related conditions. Supplementing with carnitine can help preserve cell energy levels, enhance heart muscle strength, reduce the impact of obesity and diabetes, and protect heart attack victims from dying.

    I hope you will read the Life Extension Report – it offers valuable information on the many benefits of carnitine and l-carnitine as well as debunking the sensationalist news reporting of a flawed study.

    Oh, and feel free to enjoy a nice juicy steak – in moderation of course – that red meat really is good for you!

  • New Miracle Drug For Cardiovascular Health?

    By Nurse Mark

     

    Why is it that the so-called “modern miracles” presented to us with such fanfare by Big Pharma always pale in comparison to the truly magnificent gifts that Mother Nature gives us, quietly, every day?

    Could it be that Mother Nature has had so very much longer to “get it right”? Maybe it’s true: Mother Nature Knows Best!

    Such is the case with the variety of conventional Big Pharma drug offerings for heart and cardiovascular health.

    Statins are claimed to be the answer to high cholesterol and heart disease – at the expense of some terrible side effects that we’ve discussed in other HealthBeat News articles. Rhabdomyelosis – the destruction of muscle fibers – is just one of the more common side effects. You do remember that your heart is a muscle, right? Then there are the severe and incapacitating mental effects experienced by many people – a statin fog that we’ve written about before

    Anticoagulants – AKA “blood thinners” – are handed out willy-nilly in the hopes of preventing blood clots from forming in fluttering hearts or weakened leg veins. From the original “rat poison” warfarin (coumadin) to the new “high tech” injectables, we accept the side effects; bruising, easy and prolonged bleeding from even minor injuries, and increased risk of hemorrhagic stoke (the most deadly kind) as “normal” and necessary.

    Beta Blocker drugs are passed out like candy in a vain attempt to control the damage caused by high blood pressure. When they do manage to achieve the desired effect on blood pressure they almost always do so at the expense of a person’s ability to perform normal daily functions because they are so dizzy, weak, and devoid of energy. Sexual dysfunction is common and depression is frequent. But hey – we got that blood pressure down a few points – so it’s worth it, right?

    Yes, indeed: a pill for every ill – according to Big Pharma. And if you don’t like the side effects of the pills? Well, they probably have a pill to manage those too…

    Or, we can look to Mother Nature – She has been mankind’s pharmacist for a very long time now, and if we just giver Her a chance She does a much better job of keeping us healthy than Big Pharma does.

    Let’s look at just one of Mother Nature’s tasty and effective offerings:

    Allium sativumhumble garlic – came to ancient man from Central Asia and belongs to the Alliacae plant family. It is used worldwide for it’s indispensable and distinctive flavor in cooking. It also has a vital place in traditional medicine, and as a functional food to enhance physical and mental health.

    The benefits of garlic consumption in treating a wide variety of human diseases and disorders have been known for centuries and garlic has found a special position in many cultures as a powerful preventative and therapeutic medicinal agent. The ancient Egyptians in their 3,500-year-old document the Codex Ebers, described it’s use in the treatment of heart disorders, tumors, worms, bites, and other ailments.

    In more modern times, garlic is known to inhibit the development of cardiovascular disease and to prevent cancer and other chronic diseases associated with aging.

    Over the past few decades the role of garlic in treating cardiovascular disease has received much attention – much of it likely sponsored by drug companies hoping to find a way to cash in on Mother Nature’s genius.

    Let’s look at a few of garlic’s better-known effects:

    Cholesterol and lipid-lowering effects.

    Several studies have indicated that garlic inhibits key enzymes involved in cholesterol and fatty acid synthesis, thus lowering the dreaded “bad cholesterol” levels and promoting overall cardiovascular health. (1, 2, 3, 4)

    Inhibition of platelet aggregation – known to most people as “blood thinning.”

    Since the 1990s, numerous clinical trials have been done, and all showed that garlic consumption leads to the inhibition of platelet aggregation (5, 6, 7). Performed on both normal, healthy subjects and on subjects with cardiovascular illnesses, the studies showed that no matter what form the garlic was in , whether powdered, oil, or aged extract, the garlic had a positive effect in the inhibition of platelet aggregation (abnormal blood “stickiness”) in both healthy subjects and the subjects with cardiovascular disease.

    Lowering blood pressure.

    Beginning in the 1990s, studies have been published demonstrating the effects of garlic on blood pressure (6, 8, 9, 10). Again, no matter what form of garlic was used; powdered, oil, extracts, or just garlic in the diet, all the studies showed a reduction in blood pressure.

    Reducing oxidative stress.

    Garlic beats out Big Pharma on this one – hands down. In fact, Big Pharma really doesn’t have anything to offer that they claim will reduce oxidative stress, even though it is widely known that oxidative stress can lead to the development of cardiovascular disease and certainly worsens existing cardiovascular disease. In study after study normal subjects and patients with hypertension (high blood pressure), hypercholesterolemic (high cholesterol), and tobacco smoking subjects all showed improvements in plasma (blood) antioxidant capacity, lowering of blood pressure and of cholesterol, and reduction in oxidative markers. (11, 12, 13, 14, 15)

    What else?

    Other direct heart and circulation protective effects of garlic in humans that have been reported include:

    • a decrease in unstable angina (chest pain) (16),
    • increased elasticity of blood vessels (17),
    • a decrease in peripheral arterial occlusive disease (blocked arteries) (18),
    • an increase in peripheral blood flow in healthy subjects (19),
    • an inhibiting effect on the progression of coronary calcification (hardening arteries) in patients using statin drugs (20).

    Garlic is also well-known for it’s potent antimicrobial effects as well – for example, MRSA (Methicillin-resistant Staphylococcus aureus) is a potentially deadly bacteria that has Big Pharma throwing it’s hands up in defeat because it has become resistant to the “Big Guns” antibiotics. Garlic doesn’t concede defeat however – and it is one of the few effective treatments for this dangerous antibiotic-resistant bacteria.

    But that will be the subject of another HealthBeat News article…

    Doesn’t garlic make you smell like, well, garlic?

    It depends on how you are using it. Fresh garlic cloves will certainly have you smelling like garlic – though that is not necessarily an offensive scent to many people… and other garlic preparations – oils, and extracts especially – can give a garlicky odor to your breath. Enteric garlic like Garlitrin 4000 delivers all the health benefits of fresh garlic, but does so in a special tablet that dissolves only when it reaches the small intestine where it is able to be fully-absorbed, undamaged by stomach acid. Because it dissolves and is absorbed so far along in the digestive tract it causes no garlic odor of the breath.

    A special deal on the very best Garlic – Garlitrin 4000 – 50% Off – for HealthBeat News Readers Only!

    We believe in the benefits of garlic and we want you to try it for yourself. For the months of January and Ferbruary (Heart Month!) only we invite you to try Garlitrin 4000 at half our usual low price. Here’s the Deal:

    We have a small supply of Garlitrin that has passed it’s “best by” date of November 2014. This product has been carefully kept in our climate-controlled facility, and each tablet is individually sealed in foil-backed blister packs. I am using it myself and I can tell you that it is as fresh and good as the day it was made. Worried about “best by” dates? Read our HealthBeat News article on the subject: About Those “Expiry Dates”

    Just enter the discount code “ Garlic “ (exactly as it is written, without the quotes) in the discount field when you order online and checkout and a 50% discount will be applied to your Garlitrin 4000 purchase. There are 100 enteric coated tablets individually sealed in foil blisters in each box – that is a 3-month supply!

    There has never been a better time or more reasons to try the health benefits of daily garlic!

    Click here to buy Garlitrin 4000!

    (Good only while current supplies last, applies only to on-line orders – no phone-in or mail-in orders. Current stocks of Garlitrin 4000 carry “best by” dates of 11/2014)

     

    References:

    1. Gebhardt R. Multiple inhibitory effects of garlic extracts on cholesterol biosynthesis in hepatocytes. Lipids. 1993;28:613–9.

    2. Liu L, Yeh YY. Water-soluble organosulfur compounds of garlic inhibit fatty acid and triglyceride synthesis in cultured rat hepatocytes. Lipids. 2001;36:395–400.

    3. Yeh YY, Liu L. Cholesterol-lowering effects of garlic extracts and organosulfur compounds: human and animal studies. J Nutr. 2001;131:989S–93S.

    4. Yeh YY, Yeh SM. Garlic reduces plasma lipids by inhibiting hepatic cholesterol and triacylglycerol synthesis. Lipids. 1994;29:189–93.

    5. Rahman K. Garlic and aging: new insights into an old remedy. Ageing Res Rev. 2003;2:39–56.

    6. Banerjee SK, Maulik SK. Effect of garlic on cardiovascular disorders: a review. Nutr J. 2002;1:4–14.

    7. Steiner M, Li W. Aged garlic extract, a modulator of cardiovascular risk factors: a dose-finding study on the effects of AGE on platelet functions. J Nutr. 2001;131:980S–4S.

    8. Turner B, Molgaard C, Marckmann P. Effect of garlic (Allium sativum) powder tablets on serum lipids, blood pressure and arterial stiffness in normo-lipidaemic volunteers: a randomised, double-blind, placebo-controlled trial. Br J Nutr. 2004;92:701–6.

    9. Dhawan V, Jain S. Effect of garlic supplementation on oxidised low density lipoproteins and lipid peroxidation in patients of essential hypertension. Mol Cell Biochem. 2004;266:109–15.

    10. Durak I, Kavutcu M, Aytac B, Avci A, Devrim E, Ozbek H, Ozturk HS. Effects of garlic extract consumption on blood lipid and oxidant/antioxidant parameters in humans with high blood cholesterol. J Nutr Biochem. 2004;15:373–7.

    11. Dhawan V, Jain S. Effect of garlic supplementation on oxidised low density lipoproteins and lipid peroxidation in patients of essential hypertension. Mol Cell Biochem. 2004;266:109–15.

    12. Durak I, Kavutcu M, Aytac B, Avci A, Devrim E, Ozbek H, Ozturk HS. Effects of garlic extract consumption on blood lipid and oxidant/antioxidant parameters in humans with high blood cholesterol. J Nutr Biochem. 2004;15:373–7.

    13. Munday JS, James KA, Fray LM, Kirkwood SW, Thompson KG. Daily supplementation with aged garlic extract, but not raw garlic protects low density lipoprotein against in vitro oxidation. Atherosclerosis. 1999;143:399–404.

    14. Dillion SA, Lowe GM, Billington D, Rahman K. Dietary supplementation with aged garlic extract reduces plasma and urine concentrations of 8-iso-prostagalandin F(2 alpha) in smoking and non-smoking men and women. J Nutr. 2002;132:168–71.

    15. Durak I, Aytac B, Atmaca Y, Devrim E, Avci A, Erol C, Oral D. Effects of aged garlic extract consumption on plasma and erythrocyte antioxidant parameters in atherosclerotic patients. Life Sci. 2004;75:1959–66.

    16. Li G, Shi Z, Jia H, Ju J, Wang X, Xia Z, Qin L, Ge C, Xu Y, et al. A clinical investigation on garlicin injection for the treatment of unstable angina pectoris and its actions on plasma endothelin and blood sugar levels. J Tradit Chin Med. 2000;20:243–6.

    17. Breithaupt-Grogler K, Ling M, Boudoulas H, Belz GG, Heiden M, Wenzel E, Gu LD. Protective effect of chronic garlic intake on elastic properties of aorta in the elderly. Circulation. 1997;96:2649–55.

    18. Kiesewetter H, Jung F, Jung EM, Mroweitz C, Koscielny J, Wenzel E. Effect of garlic on platelet aggregation in patients with increased risk of juvenile ischaemic attack. Eur J Clin Pharmacol. 1993;45:333–6.

    19. Anim-Nyame N, Sooranna SR, Johnson MR, Gamble J, Steer PJ. Garlic supplementation increases peripheral blood flow: a role for interleukin-6? J Nutr Biochem. 2004;15:30–6.

    20. Budoff MJ, Takasu J, Flores FR, Niihara Y, Lu B, Lau BH, Rosen RT, Amagase H. Inhibiting progression of coronary calcification using Aged Garlic Extract in patients receiving statin therapy: a preliminary study. Prev Med. 2004;39:985–91.

  • Mother Nature’s Miracle Heart Remedy

    By Nurse Mark

     

    Why is it that the so-called “modern miracles” presented to us with such fanfare by Big Pharma always pale in comparison to the truly magnificent gifts that Mother Nature gives us, quietly, every day?

    Could it be that Mother Nature has had so very much longer to “get it right”? Maybe it’s true: Mother Nature Knows Best!

    Such is the case with the variety of conventional Big Pharma drug offerings for heart and cardiovascular health.

    Statins are claimed to be the answer to high cholesterol and heart disease – at the expense of some terrible side effects that we’ve discussed in other HealthBeat News articles. Rhabdomyelosis – the destruction of muscle fibers – is just one of the more common side effects. You do remember that your heart is a muscle, right? Then there are the severe and incapacitating mental effects experienced by many people – a statin fog that we’ve written about before

    Anticoagulants – AKA “blood thinners” – are handed out willy-nilly in the hopes of preventing blood clots from forming in fluttering hearts or weakened leg veins. From the original “rat poison” warfarin (coumadin) to the new “high tech” injectables, we accept the side effects; bruising, easy and prolonged bleeding from even minor injuries, and increased risk of hemorrhagic stoke (the most deadly kind) as “normal” and necessary.

    Beta Blocker drugs are passed out like candy in a vain attempt to control the damage caused by high blood pressure. When they do manage to achieve the desired effect on blood pressure they almost always do so at the expense of a person’s ability to perform normal daily functions because they are so dizzy, weak, and devoid of energy. Sexual dysfunction is common and depression is frequent. But hey – we got that blood pressure down a few points – so it’s worth it, right?

    Yes, indeed: a pill for every ill – according to Big Pharma. And if you don’t like the side effects of the pills? Well, they probably have a pill to manage those too…

    Or, we can look to Mother Nature – She has been mankind’s pharmacist for a very long time now, and if we just giver Her a chance She does a much better job of keeping us healthy than Big Pharma does.

    Let’s look at just one of Mother Nature’s tasty and effective offerings:

    Allium sativumhumble garlic – came to ancient man from Central Asia and belongs to the Alliacae plant family. It is used worldwide for it’s indispensable and distinctive flavor in cooking. It also has a vital place in traditional medicine, and as a functional food to enhance physical and mental health.

    The benefits of garlic consumption in treating a wide variety of human diseases and disorders have been known for centuries and garlic has found a special position in many cultures as a powerful preventative and therapeutic medicinal agent. The ancient Egyptians in their 3,500-year-old document the Codex Ebers, described it’s use in the treatment of heart disorders, tumors, worms, bites, and other ailments.

    In more modern times, garlic is known to inhibit the development of cardiovascular disease and to prevent cancer and other chronic diseases associated with aging.

    Over the past few decades the role of garlic in treating cardiovascular disease has received much attention – much of it likely sponsored by drug companies hoping to find a way to cash in on Mother Nature’s genius.

    Let’s look at a few of garlic’s better-known effects:

    Cholesterol and lipid-lowering effects.

    Several studies have indicated that garlic inhibits key enzymes involved in cholesterol and fatty acid synthesis, thus lowering the dreaded “bad cholesterol” levels and promoting overall cardiovascular health. (1, 2, 3, 4)

    Inhibition of platelet aggregation – known to most people as “blood thinning.”

    Since the 1990s, numerous clinical trials have been done, and all showed that garlic consumption leads to the inhibition of platelet aggregation (5, 6, 7). Performed on both normal, healthy subjects and on subjects with cardiovascular illnesses, the studies showed that no matter what form the garlic was in , whether powdered, oil, or aged extract, the garlic had a positive effect in the inhibition of platelet aggregation (abnormal blood “stickiness”) in both healthy subjects and the subjects with cardiovascular disease.

    Lowering blood pressure.

    Beginning in the 1990s, studies have been published demonstrating the effects of garlic on blood pressure (6, 8, 9, 10). Again, no matter what form of garlic was used; powdered, oil, extracts, or just garlic in the diet, all the studies showed a reduction in blood pressure.

    Reducing oxidative stress.

    Garlic beats out Big Pharma on this one – hands down. In fact, Big Pharma really doesn’t have anything to offer that they claim will reduce oxidative stress, even though it is widely known that oxidative stress can lead to the development of cardiovascular disease and certainly worsens existing cardiovascular disease. In study after study normal subjects and patients with hypertension (high blood pressure), hypercholesterolemic (high cholesterol), and tobacco smoking subjects all showed improvements in plasma (blood) antioxidant capacity, lowering of blood pressure and of cholesterol, and reduction in oxidative markers. (11, 12, 13, 14, 15)

    What else?

    Other direct heart and circulation protective effects of garlic in humans that have been reported include:

    • a decrease in unstable angina (chest pain) (16),
    • increased elasticity of blood vessels (17),
    • a decrease in peripheral arterial occlusive disease (blocked arteries) (18),
    • an increase in peripheral blood flow in healthy subjects (19),
    • an inhibiting effect on the progression of coronary calcification (hardening arteries) in patients using statin drugs (20).

    Garlic is also well-known for it’s potent antimicrobial effects as well – for example, MRSA (Methicillin-resistant Staphylococcus aureus) is a potentially deadly bacteria that has Big Pharma throwing it’s hands up in defeat – it has become resistant to the “Big Guns” antibiotics. Garlic doesn’t concede defeat however – and it is one of the few effective treatments for this dangerous antibiotic-resistant bacteria.

    But that will be the subject of another HealthBeat News article…

    Doesn’t garlic make you smell like, well, garlic?

    It depends on how you are using it. Fresh garlic cloves will certainly have you smelling like garlic – though that is not necessarily an offensive scent to many people… and other garlic preparations – oils, and extracts especially – can give a garlicky odor to your breath. Enteric garlic like Garlitrin 4000 delivers all the health benefits of fresh garlic, but does so in a special tablet that dissolves only when it reaches the small intestine where it is able to be fully-absorbed, undamaged by stomach acid. Because it dissolves and is absorbed so far along in the digestive tract it causes no garlic odor of the breath.

    A special deal on the very best Garlic – Garlitrin 4000 – 50% Off – for HealthBeat News Readers Only!

    We believe in the benefits of garlic and we want you to try it for yourself. For the month of October only we invite you to try Garlitrin 4000 at half our usual low price. Just enter the discount code “ Garlic “ (just as it is written, without the quotes) in the discount field when you order online and checkout and a 50% discount will be applied to your Garlitrin 4000 purchase. There are 100 enteric coated tablets individually sealed in foil blisters in each box – that is a 3-month supply!

    There has never been a better time or more reasons to try the health benefits of daily garlic!

    Click here to buy Garlitrin 4000!

     

    (Good only while current supplies last, applicable only to on-line orders – no phone-in or mail-in orders, current stocks of Garlitrin 4000 carry “best by” dates of 11/2014)

    References:

    1. Gebhardt R. Multiple inhibitory effects of garlic extracts on cholesterol biosynthesis in hepatocytes. Lipids. 1993;28:613–9.

    2. Liu L, Yeh YY. Water-soluble organosulfur compounds of garlic inhibit fatty acid and triglyceride synthesis in cultured rat hepatocytes. Lipids. 2001;36:395–400.

    3. Yeh YY, Liu L. Cholesterol-lowering effects of garlic extracts and organosulfur compounds: human and animal studies. J Nutr. 2001;131:989S–93S.

    4. Yeh YY, Yeh SM. Garlic reduces plasma lipids by inhibiting hepatic cholesterol and triacylglycerol synthesis. Lipids. 1994;29:189–93.

    5. Rahman K. Garlic and aging: new insights into an old remedy. Ageing Res Rev. 2003;2:39–56.

    6. Banerjee SK, Maulik SK. Effect of garlic on cardiovascular disorders: a review. Nutr J. 2002;1:4–14.

    7. Steiner M, Li W. Aged garlic extract, a modulator of cardiovascular risk factors: a dose-finding study on the effects of AGE on platelet functions. J Nutr. 2001;131:980S–4S.

    8. Turner B, Molgaard C, Marckmann P. Effect of garlic (Allium sativum) powder tablets on serum lipids, blood pressure and arterial stiffness in normo-lipidaemic volunteers: a randomised, double-blind, placebo-controlled trial. Br J Nutr. 2004;92:701–6.

    9. Dhawan V, Jain S. Effect of garlic supplementation on oxidised low density lipoproteins and lipid peroxidation in patients of essential hypertension. Mol Cell Biochem. 2004;266:109–15.

    10. Durak I, Kavutcu M, Aytac B, Avci A, Devrim E, Ozbek H, Ozturk HS. Effects of garlic extract consumption on blood lipid and oxidant/antioxidant parameters in humans with high blood cholesterol. J Nutr Biochem. 2004;15:373–7.

    11. Dhawan V, Jain S. Effect of garlic supplementation on oxidised low density lipoproteins and lipid peroxidation in patients of essential hypertension. Mol Cell Biochem. 2004;266:109–15.

    12. Durak I, Kavutcu M, Aytac B, Avci A, Devrim E, Ozbek H, Ozturk HS. Effects of garlic extract consumption on blood lipid and oxidant/antioxidant parameters in humans with high blood cholesterol. J Nutr Biochem. 2004;15:373–7.

    13. Munday JS, James KA, Fray LM, Kirkwood SW, Thompson KG. Daily supplementation with aged garlic extract, but not raw garlic protects low density lipoprotein against in vitro oxidation. Atherosclerosis. 1999;143:399–404.

    14. Dillion SA, Lowe GM, Billington D, Rahman K. Dietary supplementation with aged garlic extract reduces plasma and urine concentrations of 8-iso-prostagalandin F(2 alpha) in smoking and non-smoking men and women. J Nutr. 2002;132:168–71.

    15. Durak I, Aytac B, Atmaca Y, Devrim E, Avci A, Erol C, Oral D. Effects of aged garlic extract consumption on plasma and erythrocyte antioxidant parameters in atherosclerotic patients. Life Sci. 2004;75:1959–66.

    16. Li G, Shi Z, Jia H, Ju J, Wang X, Xia Z, Qin L, Ge C, Xu Y, et al. A clinical investigation on garlicin injection for the treatment of unstable angina pectoris and its actions on plasma endothelin and blood sugar levels. J Tradit Chin Med. 2000;20:243–6.

    17. Breithaupt-Grogler K, Ling M, Boudoulas H, Belz GG, Heiden M, Wenzel E, Gu LD. Protective effect of chronic garlic intake on elastic properties of aorta in the elderly. Circulation. 1997;96:2649–55.

    18. Kiesewetter H, Jung F, Jung EM, Mroweitz C, Koscielny J, Wenzel E. Effect of garlic on platelet aggregation in patients with increased risk of juvenile ischaemic attack. Eur J Clin Pharmacol. 1993;45:333–6.

    19. Anim-Nyame N, Sooranna SR, Johnson MR, Gamble J, Steer PJ. Garlic supplementation increases peripheral blood flow: a role for interleukin-6? J Nutr Biochem. 2004;15:30–6.

    20. Budoff MJ, Takasu J, Flores FR, Niihara Y, Lu B, Lau BH, Rosen RT, Amagase H. Inhibiting progression of coronary calcification using Aged Garlic Extract in patients receiving statin therapy: a preliminary study. Prev Med. 2004;39:985–91.

  • This Supplement Slashes Cardiac Death Risk By Half

    By Nurse Mark

     

    This should be all over the news – but it’s not. Why? Because it’s not a drug!

    If Big Pharma managed to come up with a drug that could slash the risk of cardiac death by half they would be demanding that it be given to everyone from infancy to death, and even added to the food and water supply.

    Does that sound over-the-top? Do you think I’m exaggerating? Well, I’m not, really. Just look at the hysteria of statin drugs – with doctors, urged on by Big Pharma, suggesting that these dangerous cholesterol drugs be given to young children and with some doctors even suggesting adding statins to water supplies!

    So, just think – a drug that could slash the risk of cardiac death by half – what a block-buster!

    But it’s not a drug – it’s a supplement that you can buy over-the-counter, no prescription needed. It’s not patentable and therefore there really isn’t any profit in it for Big Pharma, so you are really not likely to ever hear about it from them or from your conventional doctor.

    So, what is this amazing supplement?

    It’s our old friend CoQ10!

    According to the Science Daily article that discusses a placebo-controlled study conducted in Europe called Q-SYMBIO:

    Coenzyme Q10 decreases all cause mortality by half, according to new results. It is the first drug to improve heart failure mortality in over a decade and should be added to standard treatment, according to experts.

     

    Wow! Does this sound too good to be true? Does this sound like “puffery” on the part of Science Daily?

    Maybe – but let’s look at the conclusions of the scientific abstract for the presentation that was made by the researchers to the 2013 conference of the European Society of Cardiology in Lisbon: (edited for readability – full abstract can be found below)

    CoQ10 treated patients had significantly lower cardiovascular mortality and lower occurrence of hospitalizations for Heart Failure. All cause mortality was also lower in the CoQ10 group, 18 patients vs. 36 patients in the placebo-group. There were fewer adverse events in the CoQ10 group compared to the placebo group.

     

    The dose of CoQ10 used to achieve this life-saving effect? A mere 100 mg taken three times a day.

    What else is CoQ10 good for?

    CoQ10 is a potent antioxidant and is vital to the energy functions of all the cells in our bodies. Learn more here.

    What about the “New” kind of CoQ10 – ubiquinol – is it really better?

    Ubiquinol and ubiquinone are two sides of the same coin – the body converts one to the other and back again. There is no solid proof that the much-hyped “new” form of CoQ10 called ubiquinol is any “better” than ubiquinone which we have been using for many years. Learn more here.

    But CoQ10 can be so darned expensive! Are the “bargain” brands any good? I need to watch my pennies!

    Yes, good quality CoQ10 is expensive. The best is made using a patented process by a Japanese company using a yeast-based process that yields a very absorbable and pure “trans” (i.e.: bio-identical – the same as your own cells make) form of CoQ10. Many bargain brands use a process that extracts a “cis” or synthetic analog form from tobacco leaves. The patented Japanese process is quite an expensive one but we believe that the “trans” form, that is, identical to that made naturally by our body, is the preferable form and worth the extra expense. The price may come down somewhat on the Japanese process CoQ10 since the Japanese company has built a facility in the US. Learn more here.

    Here is perhaps the best way to figure out your costs for CoQ10 so that you can see what might be the most economical way to take it: figure out the price per milligram (mg) for different forms. For example, Dr. Myatt sells a very high quality CoQ10 in 50 and 100 mg softgel capsules. The price works out to around a penny per milligram. She also makes available a high potency form of CoQ10 from Vitaline in 300 mg and 400 mg chewable wafers. This is the brand that was used in the N.I.H. Parkinson’s study and is known to be of the very highest quality. Though the bottles of this high dose CoQ10 might seem shockingly expensive at first glance, the cost per milligram is actually less – at just over a half-penny per mg. Despite the “sticker shock” the Vitaline CoQ10 is actually quite a bargain!

    Watching our pennies is certainly important for us all, but we need to be careful not to lose sight of the price versus value equation. And, what good are all those pennies if you don’t have your health?

     

    References:

    Science Daily Article:

    First drug to significantly improve heart failure mortality in over a decade. May 25, 2013 European Society of Cardiology (ESC)
    Summary: Coenzyme Q10 decreases all cause mortality by half, according to new results. It is the first drug to improve heart failure mortality in over a decade and should be added to standard treatment, according to experts. http://www.sciencedaily.com/releases/2013/05/130525143852.htm

    Abstract of the presentation of results from the Q-SYMBIO study:

    The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure. Results from the Q-SYMBIO study
    Authors: SA Mortensen [et al]

    On behalf: The Q-SYMBIO study investigators

    Citation: European Journal of Heart Failure ( 2013 ) 15 ( S1 ), S20

    Dysfunction of bioenergetics and energy starvation of the myocardium may be a dominant feature of heart failure (HF) and attention is directed towards a support of the myocardial metabolism. The myocardial tissue level of the essential redox component of the respiratory chain Coenzyme Q10 (CoQ10) has been found inversely related to the severity of HF. We investigated the effects of CoQ10 on patients symptoms, functional capacity and biomarker status (NT-proBNP) and the long-term outcome with morbidity and mortality.

    Methods: HF patients in New York Heart Association (NYHA) Class III or IV who were receiving current pharmacologic therapy were randomly assigned in parallel groups to CoQ10 100 mg three times daily versus placebo. The primary long-term endpoint was the time to first MACE (major adverse cardiovascular event) including unplanned hospitalization due to worsening of HF, cardiovascular death, urgent cardiac transplantation and mechanical support, using a time to first event analysis.

    Results: A total of 420 patients – CoQ10 (N=202), placebo (N=218) – were enrolled with a follow-up time of 2 years. After 3 months there was a trend with a reduced level of NT-proBNP in the CoQ10 group. After 2 years there was a significant improvement of the NYHA Class in the CoQ10 group (p=0.047). The primary endpoint was reached by 29 patients in the CoQ10 group, as compared with 55 patients in the placebo group (14 percent vs. 25 percent; hazard ratio CoQ10 vs. placebo: 2.0 (95% CI: 1.3-3.2); P=0.003) by intention to treat analysis. CoQ10 treated patients had significantly lower cardiovascular mortality (p=0.02) and lower occurrence of hospitalizations for HF (p=0.05). All cause mortality was also lower in the CoQ10 group, 18 patients vs. 36 patients in the placebo-group (9 percent vs. 17 percent; hazard ratio CoQ10 vs. placebo: 2.1 (95% CI: 1.2-3.8); p=0.01). There were fewer adverse events in the CoQ10 group compared to the placebo group (p=0.073).

    Conclusions: Q-SYMBIO is the first double-blind trial in chronic HF addressing whether CoQ10 supplementation might improve survival. The CoQ10 treated patients had reduced hospital admission rates for worsening HF and lower cardiovascular death both of which may reflect a significant improvement in cardiac function. CoQ10 treatment was safe with a reduced all cause mortality rate. CoQ10 should be considered as a part of the maintenance therapy of patients with chronic HF.

  • Help Your Heart And Health With This Food

    The “Non-Nutrient” That’s Finally Getting Respect

     

    By Dr. Myatt

     

    It used to be dismissed as mere “roughage” – good only for keeping the bowel regular.

    It’s not a “sexy supplement” or a “new breakthrough” even though Conventional Medicine is acting like they’ve just discovered it’s benefits.

    In fact, it’s not even officially classified as a nutrient, though the FDA has recognized it’s benefits and is allowing food manufacturers to place “Heart-Healthy” claims on the labels of products that contain it.

    On average, Americans get only 10% of the amount we consumed 100 years ago, and our health may be seriously suffering as a result.

    What is this important “non nutrient” that we’re missing? Dietary fiber.

     

    You might have seen the study of nearly 400,000 people, conducted by the National Institutes of Health and American Association of Retired People and published in The Archives Of Internal Medicine showing that men aged 50 and older who ate the most fiber were up to 56 percent less likely to die from cardiovascular disease, infectious diseases and respiratory ailments, compared to those who ate the least.

    For women aged 50 and up, a high-fiber diet lowered risk of death from these causes by nearly 60 percent.

    WOW – I’ll have some of that – sign me up!

    If fiber was a patented drug we would be hearing all about it, with doctors writing prescriptions for it like they do for blood pressure drugs or cholesterol pills – but it’s not, so it doesn’t get much respect from Conventional Medicine or Big Pharma.

    “Fiber” refers to a number of indigestible carbohydrates found in the outer layers of plants. Humans lack enzymes to break down most types of fiber, so they pass through the digestive system relatively unchanged and do not provide nutrients or significant calories – hence the derogatory term “roughage.”

    In spite of this indigestibility, fiber has a surprising number of health benefits. In fact, as the recent NIH / AARP study confirms, consuming adequate daily fiber is one of the most important health measures anyone can take.

    Twenty-Five Health Benefits of Fiber — Who Knew?

    There are numerous “sub-classes” of fiber, but the two main types are I.) soluble and II.) insoluble fiber. Both types are beneficial to health and both typically occur together in nature. They each offer independent health benefits. Here are twenty-five known health benefits that fiber provides.

    Bowel Benefits:

    1.) Relieves constipation. Insoluble fiber absorbs large amounts of water in the colon. This makes stools softer and easier to pass. Most people who increase fiber intake will notice improved bowel function in 31-39 hours.

    2.) Relieves diarrhea. It may seem paradoxical that a substance which helps constipation also helps diarrhea, but that’s just what fiber does. Insoluble fiber binds watery stool in the colon, helping turn “watery” into “formed.” Fiber is known to offer significant improvement to those with diarrhea.

    3.) Helps prevent hemorrhoids. Constipation is a leading cause of hemorrhoids. Because fiber-rich stools are easier to pass, less straining is necessary. Diets high in fiber have been shown to prevent and relieve hemorrhoids.

    4.) Reduces risk of diverticular disease. In cultures that consume high-fiber diets, diverticular disease is relatively unknown. That’s because high fiber intake “exercises” the colon, prevents excess bowel gas and absorbs toxins, all of which lead to the “bowel herniation” disease known as diverticulitis. Increased fiber intake is currently recommended in Western medicine as primary prevention for the disease.

    5.) Helps Irritable bowel syndrome (IBS). IBS is characterized by constipation, diarrhea, or alternating constipation/diarrhea. Regardless of type, increased fiber intake has been shown to improve IBS symptoms.

    6.) Improves bowel flora. “Flora” refers to the “good bugs” (healthy bacteria) that colonize the large intestine (colon). Antibiotics, drugs, food allergies, high sugar diets and junk food alter this “bowel garden” in favor of the “bad bugs.” Certain types of fiber are rich in substances the “feed” bowel flora and help keep the balance of good bacteria in the colon at a normal level.

    7.) Helps prevent colon cancer. Although research has been controversial, observational studies in the 1970s showed that African natives consuming high-fiber diets had a much lower incidence of colorectal carcinoma. Since the “risk” of increased fiber consumption is so small, the “US Pharmacist,” states…

    “…with no clearly negative data about fiber, it makes sense to increase fiber intake just in case the positive studies did reveal an actual link. The patient will also experience the ancillary benefits of fiber consumption, such as reduction in cholesterol (with psyllium), prevention of constipation, and reducing risk of hemorrhoids.”

    8.) Appendicitis: studies show a correlation between the development of appendicitis and low fiber intake. A diet high in fiber may help prevent appendicitis.

    Whew… that’s just the bowel benefits! Fiber also helps prevent heart disease in multiple ways.

    9.) Lowers Total cholesterol. According to the FDA, soluble fiber meets the standard for reduction of risk from coronary heart disease. Psyllium husk is also able to reduce the risk of coronary heart disease as it contains a soluble fiber similar to beta-glucan.

    10.) Lowers triglycerides. Higher dietary fiber is associated with lower triglyceride levels.

    11.) Raises HDL. Fiber may even raise HDL — the “good cholesterol” — levels.

    12.) Lowers LDL Cholesterol. In addition to total cholesterol, increased fiber lowers LDL — the “bad cholesterol” — levels.

    13.) Aids Weight loss. Fiber helps prevent weight gain and assists weight loss several ways. The “bulking action” of fiber leads to an earlier feeling of satiety, meaning that one feels satisfied with less high-calorie food when the meal contains a lot of fiber. Fiber helps bind and absorb dietary fat, making it less available for assimilation. This means that some fat may be “lost” through the digestive tract when the meal is high in insoluble fiber.

    14.) Lowers Overall risk of Coronary Artery Disease. Perhaps because of a combination of the above-listed lipid-normalizing factors, some studies have shown an overall protective effect of higher fiber intake against coronary heart disease.

    Fiber also benefits blood sugar levels and diabetes…

    15.) Helps Type I Diabetes. Eaten with meals, high-fiber supplements like guar gum reduced the rise in blood sugar following meals in people with type 1 diabetes. In one trial, a low-glycemic-index diet containing 50 grams of daily fiber improved blood sugar control and helped prevent hypoglycemic episodes in people with type 1 diabetes taking two or more insulin injections per day.

    16.) Improves Type II Diabetes. High-fiber diets have been shown to work better in controlling diabetes than the American Diabetic Association (ADA)-recommended diet, and may control blood sugar levels as well as oral diabetic drugs.

    One study compared participants eating the the ADA diet (supplying 24 grams of daily fiber) or a high-fiber diet (containing 50 grams daily fiber) for six weeks. Those eating the high-fiber diet for six weeks had an average 10% lower glucose level than people eating the ADA diet. Insulin levels were 12% lower in the high-fiber group compared to those in the ADA diet group. The high fiber group also had decreased  glycosylated hemoglobin levels, a measure of long-term blood glucose regulation.

    High-fiber supplements such as psyllium, guar gum and pectin have shown improved glucose tolerance.

    More systemic benefits of fiber:

    17.) Gallstone prevention. Rapid digestion of carbohydrates leads to fast release of glucose (sugar) into the bloodstream. In response, the body releases large amounts of insulin. High insulin levels contribute to gallstone formation. Because dietary fiber slows the release of carbohydrates (and corresponding insulin), fiber helps prevent gallstone formation.

    18.) Kidney stone prevention. Low intakes of dietary fiber have been found to correlate with increased kidney stone formation, and higher intakes of fiber appear to be protective against stone formation.

    19.) Varicose veins. “Straining at stool” caused by fiber-deficiency constipation, has been found in some studies to cause varicose veins. Populations with lower fiber intakes have higher rates of varicosities.

    Fiber may even be important in prevention of certain types of cancer…

    20.) Colon Cancer Prevention. Diets higher in fiber have been shown in some studies to reduce the risk of colon cancer.

    21.) Breast cancer prevention. Higher fiber diets are associated with lower breast cancer risk. Some studies have shown up to a 50% decreased risk with higher fiber intakes. After diagnosis, a high fiber diet may decrease the risk of  breast cancer reoccurrence.

    22.) Pancreatic cancer prevention. High fiber diets are associated with lower risk of pancreatic cancer.

    23.) Endometrial cancer prevention. Higher fiber has been shown in some studies to protect against endometrial cancer.

    24.) Prostate cancer prevention. Diets higher in fiber may be associated with lower risk of prostate cancer. After diagnosis, a high fiber diet may decrease the risk of  prostate cancer reoccurrence.

    25.) Cancer prevention in general. Some studies have found that high fiber diets help prevent cancer in general, regardless of type.

    Recommendations vs. Reality – How Much Do We Need?

    The average daily American fiber intake is estimated at 14 to 15 g, significantly less than the American Dietetic Association recommendation of 20 to 35 g for adults, 25 g daily for girls ages 9 through 18 years and 31 to 38 g for boys ages 9 through 18. The American Heart Association recommends 25 to 30 g daily.

    Based on dietary intakes of long-lived populations (who typically consume 40-60 grams or more of fiber per day), many holistic physicians recommend aiming for a minimum of 30 grams of daily fiber.

    In my clinical experience, I find that most people over-estimate their fiber intake because they are unaware of the fiber content of many of the foods they eat (see http://www.drmyattswellnessclub.com/rate_your_plate.htm).

    Since fiber has proven itself to be such an important “non nutrient” for good health, increased dietary consumption and/or supplementation can be considered a wise choice for optimal health and disease prevention.

    Beware of so-called “healthy foods” that claim to be “high fiber” – whole wheat bread products, granola bars, even “high fiber” pasta – many of these foods have only marginally more fiber than their regular counterparts, with every bit as much carbohydrates.

    We wrote about this “honesty in labeling” problem in our HealthBeat News article called Low Carb Lies.

    To help those who would like to increase their fiber intake while keeping their carb intake under control we have developed some great recipes: Dr. Myatt’s Blueberry Muffins, Dr. Myatt’s Fiber Bread, and Dr. Myatt’s Super Shakes.

    Dr. Myatt has formulated an excellent fiber supplement – check out Maxi Fiber!

    Find more information about Psyllium Here.

     

    Additional reading and reference materials:

    Dietary Fiber Definition Committee, Report of the Dietary Fiber Definition Committee to the Board of Directors of the American Association of Cereal Chemists: The Definition of Dietary Fiber.  St Paul, MN AACC International March 2001;112- 126

    Spiller  GAed CRC Handbook of Dietary Fiber in Human Nutrition. 3rd ed. Boca Raton, FL CRC Press 2001;

    Anderson  JWBaird  PDavis  RH  Jr  et al.  Health benefits of dietary fiber. Nutr Rev 2009;67 (4) 188- 205
    PubMed

    Todd  SWoodward  MTunstall-Pedoe  HBolton-Smith  C Dietary antioxidant vitamins and fiber in the etiology of cardiovascular disease and all-causes mortality: results from the Scottish Heart Health Study. Am J Epidemiol 1999;150 (10) 1073- 1080 PubMed

    Streppel  MTOcké  MCBoshuizen  HCKok  FJKromhout  D Dietary fiber intake in relation to coronary heart disease and all-cause mortality over 40 y: the Zutphen Study. Am J Clin Nutr 2008;88 (4) 1119- 1125 PubMed

    Bazzano  LAHe  JOgden  LGLoria  CMWhelton  PKNational Health and Nutrition Examination Survey I Epidemiologic Follow-up Study, Dietary fiber intake and reduced risk of coronary heart disease in US men and women: the National Health and Nutrition Examination Survey I Epidemiologic Follow-up Study. Arch Intern Med 2003;163 (16) 1897- 1904 PubMed

    Schatzkin  ASubar  AFThompson  FE  et al.  Design and serendipity in establishing a large cohort with wide dietary intake distributions: the National Institutes of Health–American Association of Retired Persons Diet and Health Study. Am J Epidemiol 2001;154 (12) 1119- 1125 PubMed

    Tippett  KSCypel  YS Design and Operation: The Continuing Survey of Food Intakes by Individuals and Diet and Health Knowledge Survey, 1994-96.  Washington, DC US Dept of Agriculture, Agriculture Research Service1998;Nationwide Food Surveys Report No. 96-1

    Wolk  AManson  JEStampfer  MJ  et al.  Long-term intake of dietary fiber and decreased risk of coronary heart disease among women. JAMA 1999;281 (21) 1998- 2004 PubMed

    Rimm  EBAscherio  AGiovannucci  ESpiegelman  DStampfer  MJWillett  WC Vegetable, fruit, and cereal fiber intake and risk of coronary heart disease among men. JAMA 1996;275 (6) 447- 451 PubMed

    Pietinen  PRimm  EBKorhonen  P  et al.  Intake of dietary fiber and risk of coronary heart disease in a cohort of Finnish men: the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. Circulation 1996;94 (11) 2720- 2727 PubMed

    Eshak  ESIso  HDate  C  et al. JACC Study Group, Dietary fiber intake is associated with reduced risk of mortality from cardiovascular disease among Japanese men and women. J Nutr 2010;140 (8) 1445- 1453 PubMed

    Pereira  MAO’Reilly  EAugustsson  K  et al.  Dietary fiber and risk of coronary heart disease: a pooled analysis of cohort studies. Arch Intern Med 2004;164 (4) 370- 376 PubMed

    Brown  LRosner  BWillett  WWSacks  FM Cholesterol-lowering effects of dietary fiber: a meta-analysis. Am J Clin Nutr 1999;69 (1) 30- 42 PubMed

    Pereira  MAJacobs  DR  JrPins  JJ  et al.  Effect of whole grains on insulin sensitivity in overweight hyperinsulinemic adults. Am J Clin Nutr 2002;75 (5) 848- 855 PubMed

    Streppel  MTArends  LRvan ‘t Veer  PGrobbee  DEGeleijnse  JM Dietary fiber and blood pressure: a meta-analysis of randomized placebo-controlled trials. Arch Intern Med 2005;165 (2) 150- 156 PubMed

    World Cancer Research Fund–American Institute for Cancer Research, Food, Nutrition, Physical Activity, and the Prevention of Cancer: A Global Perspective.  Washington, DC American Institute for Cancer Research 2007;

    Schottenfeld  DedFraumeni  JFed Cancer Epidemiology and Prevention. 3rd ed. New York, NY Oxford University Press 2006;

    Nathan  C Points of control in inflammation. Nature 2002;420 (6917) 846- 852 PubMed

    Ma  YGriffith  JAChasan-Taber  L  et al.  Association between dietary fiber and serum C-reactive protein. Am J Clin Nutr 2006;83 (4) 760- 766 PubMed

    King  DEEgan  BMGeesey  ME Relation of dietary fat and fiber to elevation of C-reactive protein. Am J Cardiol 2003;92 (11) 1335- 1339 PubMed

    Wannamethee  SGWhincup  PHThomas  MCSattar  N Associations between dietary fiber and inflammation, hepatic function, and risk of type 2 diabetes in older men: potential mechanisms for the benefits of fiber on diabetes risk. Diabetes Care 2009;32 (10) 1823- 1825 PubMed

    Ma  YHébert  JRLi  W  et al.  Association between dietary fiber and markers of systemic inflammation in the Women’s Health Initiative Observational Study. Nutrition 2008;24 (10) 941- 949 PubMed

    Jacobs  DR  JrAndersen  LFBlomhoff  R Whole-grain consumption is associated with a reduced risk of noncardiovascular, noncancer death attributed to inflammatory diseases in the Iowa Women’s Health Study. Am J Clin Nutr 2007;85 (6) 1606- 1614 PubMed

    Aldoori  WHGiovannucci  ELRockett  HRSampson  LRimm  EBWillett  WC A prospective study of dietary fiber types and symptomatic diverticular disease in men. J Nutr 1998;128 (4) 714- 719 PubMed

    Aldoori  WHGiovannucci  ELStampfer  MJRimm  EBWing  ALWillett  WC Prospective study of diet and the risk of duodenal ulcer in men. Am J Epidemiol 1997;145 (1) 42- 50 PubMed
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