HealthBeat News

Category: Family Health

  • Fungus, Yeasts and Molds: Hidden Cause of Many “Unexplained” Diseases

    Every day, thousands of microscopic, decay-eating organisms find their way into our bodies in the food we eat and the air we breathe. These organisms are part of  The Fungi Kingdom and include yeasts, molds, mildew, mushrooms, fungi and others. Although most fungi feed on dead and decaying organisms, a number of them also feed on living organisms. Athlete’s foot is a common fungus which feeds on a living host.

    The entire class of Fungi are “opportunistic,” and the ones which feed on humans can establish themselves in a human body during a time of weakness, such as during an infection or when the immune system is suppressed with drugs. There are also many fungi that do not require a weak immune system in order to establish themselves in a host. In addition to the direct effects of the fungi, which act like parasites in a human host, many also manufacture highly toxic substances called “mycotoxins.”

    Who Cares About Fungi and Mycotoxins?

    Fungi produce toxins called mycotoxins (“Myco” from the Greek “Mykes”, means “fungus”). Mycotoxins cannot be destroyed by heat, are known to suppress the immune system, and have a wide range of effects in both animals and humans. A number of these mycotoxins are quite poisonous.

    Aflatoxin, a common toxin found in peanuts and some grains and a result of Aspergillus flavus fungus, is one of the most potent carcinogens known to man. Because of this, peanuts and grains must be constantly “screened” for aflatoxin. Even with this government-mandated screening, a person eating according to the US Food-pyramid is eating between 0.15-0.5 grams per day. (A lethal dose is considered to be 10-20mg). But at these everyday, low-grade exposures, negative health effects can still be experienced.

    Symptoms and Diseases Associated with Mycotoxins and the Fungi Kingdom

    When the World Health Organization recently convened, Dr. A.V. Costantini, head of the organization, an internist who modestly claims to be a “just a country doctor,” listed fourteen diseases wherein fungal (mold & Candida Albicans) forms of microorganisms have been found include the following: atherosclerosis, cancer, AIDS, diabetes mellitus, rheumatoid arthritis, Sjogren’s syndrome, systemic lupus , erythematosus, gout, Crohn’s disease, Multiple sclerosis, hyperactivity syndrome, Infertility, psoriasis, cirrhosis of the liver, Alzheimer’s disease, Scleroderma, Raynaud’s Disease, sarcoidosis, kidney stones, amyloidosis, vasculitis, and Cushing’s disease. 

    Other conditions known to be caused by fungi, yeasts and their mycotoxins include: postpartum depression, immune system weakness, bladder disease (especially non-bacterial interstitial cystitis in women and chronic non-bacterial prostatitis in men), pneumonitis and lung infections, endometriosis and weight gain.

    A person suffering from yeast of fungal overgrowth may have any of these symptoms:

    • In the intestinal tract: bloating, excessive feeling of fullness, diarrhea, constipation, alternating diarrhea and constipation, “rolling gas,” abdominal cramping, heartburn, indigestion, gas or belching, mucous in the stool, hemorrhoids.
    • In the female genital tract: recurrent yeast vaginitis, persistent vaginal itching or burning, persistent vaginal discharge, endometriosis, PMS.
    • In the male genital tract: prostatitis, impotence, loss of sexual desire.
    • In the urinary tract: urgency or urinary frequency, recurrent urinary tract “infections” but bacteria are NOT found to be the cause.
    • In the nervous system: numbness, burning, or tingling, spots in front of the eyes, erratic vision, impaired coordination, irritability or jitteriness, dizziness or loss of balance, failing vision, ear pain or deafness.
    • In the immune system: rashes, post nasal drip, sore or dry throat, wheezing or shortness of breath, recurrent infections, burning or tearing of eyes, cough.
    • In the skin and mucous membranes: recurrent skin fungal infections, nail-bed fungus, “jock itch,” thrush (yeast overgrowth in the mouth and esophagus)
    • In general: fatigue, mental “cloudiness,” joint aches and pains, obesity, depression, memory loss.

    There are quite probably many other medical conditions associated with fungi, yeasts and mycotoxins in the human body. Because this is a largely overlooked topic in conventional medicine, our understanding of the disease-fungi connection is weak at best.

    Your conventional doctor is unlikely to be aware of or to tell you about these mycotoxin-induced problems. You can learn more about candidiasis here: http://www.drmyattswellnessclub.com/candidiasis.htm . If you believe that you may be experiencing any of these symptoms or problems a Candida stool test is a good place to start your investigation.
     
    References:
    Mycotoxins in the food chain: human health implications. Asia Pac J Clin Nutr. 2007;16 Suppl 1:95-101.
    Contamination of food with mycotoxins and human health. Arh Hig Rada Toksikol. 2001 Mar;52(1):23-35.
    Limits and regulations for mycotoxins in food and feed.
    Toxic effects of mycotoxins in humans. Bull World Health Organ. 1999;77(9):754-66
    Toxins of filamentous fungi. Food Addit Contam. 2005 Feb;22(2):150-7
    Mycotoxins in infant cereal foods from the Canadian retail market. Food Addit Contam. 2003 May;20(5):494-504.

  • Lower Cholesterol Naturally – Better Cholesterol Management with Vitamins and Herbs

    Your Cholesterol Questions Answered

    What can be done if you’ve been told that you have "high cholesterol?" I’ve been getting questions "in spades" this week, so it’s time for a cholesterol management update! Like Lennie who wrote "I would like to know what supplements you recommend to lower LDL besides diet. I do not want to take statins. Thanks for your news letter I do read it. Blessings, Lennie."

    Perhaps your conventional doctor found your cholesterol levels to be "high" (and there are differing opinions on what "too high" really is, because cholesterol is only ONE of a number of heart risk factors). He or she has probably advised you to start taking a "statin" drug. You will likely be sent off with a prescription for the statin-de-jour along with a recommendation to "eat less cholesterol and cut down on fats." If you do a little research, you will discover that statin drugs have some worrisome side-effects, including elevated liver enzymes (indicating liver distress) and rhabdomyelosis (muscle damage; NOTE: the heart is a muscle). You might also see that there are dozens, maybe even hundreds, of natural remedies, all claiming to be "the best" for safely lowering cholesterol levels.

    We (Dr. Myatt and Nurse Mark) chuckle when we get questions from Wellness Club members asking if we have heard about the latest and greatest pill or potion or "cure" – we’ve heard ’em all and then some!

    While statin drugs are being marketed as the next best drug since antibiotics, the dangers and expense of these drugs are rarely mentioned. All the while, well-proven natural remedies exist to reduce LDL cholesterol levels, total cholesterol levels, triglycerides and various other heart risk factors. Along with proven natural remedies come another half-dozen substances that are seen to be helpful but are not as well researched. And of course, as with all other natural remedies, there are an entire array of poorly-researched, unproven remedies that rely on anecdotal "patient success stories" in their glowingly inflated sales pitches. Beware – these "also-rans" aren’t known to perform like proven remedies and may leave you sorely disappointed with the results.

    The Big Three Remedies for High Cholesterol

    1.) Niacin The most well-studied natural agent for cholesterol improvement is niacin, a B complex vitamin. Niacin’s effect on cholesterol has been known since the 1950’s when it was found to be a highly effective cholesterol lowering agent. Studies have shown that niacin not only lowers LDL cholesterol, but also Lp(a), triglyceride, and fibrinogen (a blood protein that causes clot formation) levels, while it simultaneously raises beneficial HDL cholesterol levels. The Coronary Drug Project, an intensive and extensive evaluation of cholesterol-lowering drugs demonstrated that niacin was the only cholesterol-lowering agent that actually reduced overall mortality. Its effects were also found to be long lived, protecting patients in the study years after they had stopped taking it. Here is how niacin compares to cholesterol-lowering drugs:

    Drug Class LDL HDL TG
    BAR’s
    (Bile Acid Resins)    		 decreased
    15-30%    		 increased
    3-5%    		 +/-
    Niacin decreased
    5-25%    		 increased
    15-35%    		 decreased
    20-50%
    Statins decreased
    18-60%    		 increased
    5-15%    		 decreased
    7-30%
    Fibric Acids decreased
    5-20%    		 increased
    10-20%    		 decreased
    20-50%
    Cholesterol Absorption Inhibitors decreased
    20%    		 +/- decreased
    8%

    Note that although statins can have a bigger impact on LDL cholesterol levels, niacin is more effective at lowering tryglycerides and raising HDL (the good cholesterol). Also be aware that cholesterol levels can be too low. Cholesterol levels under 140 are associated with an increased risk of strokes.

    Like any substance, high-dose niacin is not without cautions. It’s side effects are well known, the most common being a "niacin flush" – an uncomfortable flushing or hot feeling experienced by some people after taking standard niacin. Niacin can be toxic to the liver when taken in a "time release" form that was developed to avoid the problem of the "niacin flush" that made some patients reluctant to use it. Niacin can alter blood sugar control and so should be used under medical supervision in people with diabetes. It is also important to monitor both cholesterol levels and liver enzyme levels every three months or so while using niacin, as with a statin drug.

    Dr. Myatt recommends a form of niacin called inositol hexaniacinate, a No-Flush Niacin that is very well tolerated.

    If niacin is so great, why don’t the drug companies sell it, and why doesn’t my doctor tell me to take it, you ask? Well, though the studies strongly supports the use of niacin, it has also been victim of a lot of misinformation – your doctor may be ill-informed about it’s benefits, while he or she has certainly been told all about the "benefits" of statins. Niacin is a widely available "generic" substance, meaning it cannot be patented, and the drug companies do not stand to make from it the massive profits that th
    e other cholesterol-lowering drugs have generated for them.

    As a result, one rarely sees niacin advertised in the way that the expensive statin drugs are. Still, niacin should be considered as the first choice in a cholesterol-lowering treatment.

    NOTE: If your doctor DOES prescribe niacin, it will most likely be the pharmaceutical "timed release" version. Studies show that timed release niacin is toxic to the liver and DOES NOT have better benefit than NON timed-release formulas. DO NOT TAKE timed-release niacin for high cholesterol!

    2.) Red Rice Yeast is next in importance. This substance is actually the result of a fungus that grows on white rice, turning it a red color. It has been known for centuries, and used as a colorant in oriental cuisine, and to make a form of red sake (rice wine).

    The active component in Red Rice Yeast is a compound called mevinolin, which is identical to the prescription drug, lovastatin. The drug companies created lovastatin in the laboratory in 1987 also using a fungus, Aspergillus terreus. The active ingredient in Red Rice Yeast was discovered and isolated a decade earlier.

    Red Rice Yeast has been proven to be just as effective as the modern statin drugs at lowering LDL cholesterol. Taken in high doses, it can have some of the same risks as the modern statin drugs – namely a risk of liver damage and also of rhabdomyolysis, a condition that includes muscle deterioration. Anyone taking this or any statin drug should have a baseline liver enzyme check and have their liver enzymes checked at three months into treatment. But risks are small (about 2%). The good news is that it is thought that there is a synergistic effect obtained from other related compounds in Red Rice Yeast which allows much smaller doses to be effective. A typical dose of a statin drug would be in the range of 20-80mg/day while a typical dose of Red Rice Yeast would be about 2.5-10mg/day.

    Neither Red Rice Yeast nor statin drugs should be taken with grapefruit juice, as this can cause a dangerous buildup of the statin compounds in the body.

    Due to drug company pressure on the FDA, many Red Rice Yeast products have been taken off the market because they contain— guess what?— the active ingredient for lowering cholesterol! The FDA said that this made them a drug. Statin drugs are now a 10+ billion dollar a year business for the drug companies (statins are the biggest selling drug of all time), and I believe the they do not want any competition from a natural remedy, especially one that works successfully, has far less negative side effects, and can be taken for about 1/4 the monthly cost of the drug versions. Although the FDA has waffled back and forth about Red Rice Yeast, it is still currently available and should be added to your cholesterol-lowering program if niacin alone fails to help within 8 weeks OR if your total cholesterol is above 240 or your hs-CRP is elevated.

    3.) CoQ10 is a naturally-occurring antioxidant produced in the human body. It is vitally involved in energy production. CoQ10 functions as an "energizer" to mitochondria, the body’s energy producing units. Muscles, and the heart in particular, have high requirements for CoQ10. Although CoQ10 is produced by the body, age, nutrient deficiencies, disease and some medications can lower the body’s CoQ10 levels. Cholesterol-lowering drugs (statins) are known to deplete CoQ10. (The original patent-holders of statins wanted to add CoQ10 to the drug because of this known depletion; the FDA denied their request). Everyone taking a statin drug should also be taking CoQ10. In fact, because CoQ10 is necessary for normal heart function, I strongly recommend it’s use for any type of heart disease, including coronary artery disease, arrhythmia, high blood pressure and as part of a cholesterol-lowering program.

    Other Proven Cholesterol-Lowering Agents

    Garlic is another well-known cholesterol-lowering agent is with a wide spectrum of additional beneficial effects including blood pressure regulation, effective antibiotic scope and potent immune stimulant. Here however we are interested in garlic’s proven ability to lower LDL cholesterol when taken in appropriate doses of preparations that contains the the ingredient allicin. Allicin is the product of the substance alliin and the enzyme alliinase, and is fragile, dissipating quickly and easily during processing. A minimum therapeutic intake of allicin is considered to be about 4000 mcg. That is the equivalent to about one to four cloves of whole fresh garlic (depending on the size of the clove.) It is true that simply eating garlic (and it’s cousin onion) can have an excellent effect for lowering LDL cholesterol, blood pressure, and blood fibrinogen levels. Please remember that this effect is lost when garlic or onion is cooked, as cooking quickly destroys the active ingredient allicin. Anyone looking to buy garlic supplements should be aware of the German Commission E, a panel of experts which sets standards for dosage requirements to allow for therapeutic claims. Check the label to make sure the supplement you are considering meets their standards for strength and purity.

    Vitamin C has a well-studied positive effect on lowering total cholesterol and triglyceride levels while raising beneficial HDL levels. Vitamin C supplementation is valuable for many other reasons – it is an powerful antioxidant, and an immune enhancer. If you are considering using higher doses of vitamin C, use buffered vitamin C to avoid stomach upset. Also remember that Dr. Myatt’s Maxi-Multi contains 1,200 mg of this important vitamin when taken in the recommended daily dose.

    Fiber has a time-honored place in any cholesterol-lowering regimen. High intakes of soluble fiber have been shown to lower both overall and LDL cholesterol levels. Unfortunately, such high intakes of fiber can cause gastrointestinal upset in many people, and this causes them to not take effective doses. Psyllium and oat bran are two of the most-studied, and are easily available to add to the diet. You should NOT take psyllium at the same time you take the prescription drugs carbamazepine, lithium, digitalis or nitrofurantoin because psyllium will decrease their absorption and effectiveness.

    Another form of fiber that is demonstrating great promise as a cholesterol-lowering aid is chitosan which is a substance made from the shell
    s of shellfish. Chitosan has the effect of binding fat and cholesterol in the digestive tract. It is so effective at this that it will absorb as much as seven to eight times it’s own weight in fat and bile which are then passed through the bowel and excreted. Because of it’s fat-binding ability, chitosan is valuable as a weight loss aid as well as a cholesterol-normalizing agent. There are just a couple of caveats regarding chitosan: first, like any other fiber, chitosan can interfere with the absorption of certain nutrients and trace minerals. These should be taken at times other than when chitosan when is taken. Secondly, because chitosan is derived from the exoskeletons (shells) of shellfish, people with seafood allergies should use caution.

    The above list is the top half-dozen, proven, tested, effective cholesterol-lowering supplements and agents. They are not the only things in our armamentarium (that’s a medical word for "bag of tricks"!) though. Some of the "lesser lights" are not as well proven, or not as specifically effective at lowering cholesterol, but they may still be very valuable as a part of a coordinated cholesterol-lowering and health improving plan.

    More Cholesterol-Lowering Substances

    Artichoke has been studied since the 1930’s and found to have excellent effects on both atherosclerotic plaque and cholesterol and LDL levels. It is also highly protective, and may even be regenerative to the liver. It also possesses antioxidant properties. It is a valuable addition to a person’s daily supplementation. Dr. Myatt makes this available in combination with Milk Thistle which is a potent liver protector with regenerative properties and a powerful antioxidant and Turmeric which is a marvelous anti-inflammatory, antioxidant, liver-protective (on a par with milk thistle), anti-tumorgenic herb that also helps maintain normal blood viscosity. My Milk Thistle Plus+ Formula combines all three of these herbs for a powerful liver-enhancing effect.

    Turmeric has been shown in a number of studies to have cholesterol-lowering effects of it’s own. This, in addition to it’s other benefits as described above make it a "must do" in any daily supplementation program. Turmeric also inhibits platelet aggregation (med-speak for blood clotting) and serves as a natural cox-2 inhibitor like the prescription drug Vioxx.

    Gugulipid is an ancient remedy that is being "rediscovered" by the western medical establishment. Gugulipid is made from the resin of the commiphora mukul tree of north central India and has been used for thousands of years to alleviate problems associated with obesity, acne, viral infections, and other ailments. It has also been shown in some limited but significant studies to reduce cholesterol and LDL levels and increase HDL levels within three to four weeks. It is certainly worth considering adding this to a cholesterol-lowering regimen.

    Green Tea has also been the subject of some promising and even exciting research. Green tea serves as a potent antioxidant, preventing the oxidation of LDL in the arteries. The cholesterol-lowering effects of Green tea have been shown in numerous animal and human studies. Green tea catechins act to limit the rise in blood cholesterol according to a 1996 Japanese study. Further, Green tea has been shown to elevate HDL, and serves as a natural ACE inhibitor, lowering blood pressure. These benefits can be obtained by drinking up to 10 cups of Green tea daily, or taking one to two capsules of Green tea extract daily.

    Fish Oil has been shown to reduce high levels of triglycerides by an average of 35%. It does not appear to reduce cholesterol to that extent, but it does offer benefits when as part of an integrated therapy program. Scientific studies have demonstrated that alpha-linolenic acid (from flax or perilla oil) reduces the incidence of atherosclerosis, stroke, and second heart attacks. One study showed a 70% reduction in second heart attacks in those consuming this type of fatty acid.

    Vitamin E protects us from more than 80 diseases and illnesses, including protecting us from the inhibiting the effects of oxidation of LDL and the development of atherosclerotic disease. Studies have also shown it to be effective as some hypocholesterolemic (cholesterol-lowering) drugs. Anyone considering adding vitamin E to their regimen should also add Selenium which works with vitamin E to prevent LDL oxidation. Both of these nutrients are found in Dr. Myatt’s Maxi-Multi.

    Policosanol refers to a group of eight solid alcohols derived from sugar cane wax. Octacosanol is the major constituent of policosanol and proponents of this substance claim that Octacosanol is remarkably safe and effective at reducing cholesterol levels, and at reducing platelet aggregation. Current supplies are from Cuba and, in my opinion, too expensive. As the price comes down and the research some up, this may prove to be a worthy cholesterol-lowering agent. (The research would have to be VAST to surpass niacin, however).

    Finally, Soy has been shown to confer numerous benefits through it’s isoflavones – genistein, daidzein, and glycitein. According to a study completed in 1997, "Potential mechanisms by which soy isoflavones might prevent atherosclerosis include a beneficial effect on plasma lipid concentrations, antioxidant effects, antiproliferative and antimigratory effects on smooth muscle cells, effects on thrombus formation, and maintenance of normal vascular reactivity." Bottom line: if you want to reduce your risk of heart disease and elevated cholesterol levels, it is worth adding soy to your diet.

    Unproven Cholesterol "Cures"

    We’ve talked about the proven first line remedies and the second line "helpful’s," now let’s talk about some substances that have been touted without proof to back them up.

    Coral Calcium – promoted as the cure for every thing from cancer to high cholesterol to bad breath to spiritual weakness. Many of it’s top promoters are facing criminal prosecution. Avoid it. Not only does coral calcium often contain high lead levels, it is destructive to the coral reefs where it is derived. Calcium alone is not a proven cholesterol-lowering remedy; neither is coral calcium. If you need additional calcium/magnesium/bone nutrients, consider taking Cal-Mag Amino.

    Various teas have been touted as total cholesterol cures, no doubt riding on the coattails of accepted Green Tea studies. Don’t believe them – Green Tea is an important part of a cholesterol-control program, but teas are not the whole answer!

    Cinnamon capsules have recently been promoted as a cholesterol-reducing agent. We are not aware of any solid studies to support this. Cinnamon does seem to have a beneficial effect on blood sugar levels of type II diabetics though. The capsules seem a bit expensive, when you can simply add this spice to your food and beverages – try it in tea!

    Vinegar, and most especially apple cider vinegar, have also enjoyed some popularity as folk remedies for high cholesterol. Again, there is no scientific evidence of beneficial effect – though "anecdotal evidence" of the "my best friend’s great aunt’s late husband used it every day ’till he died" variety is plentiful…

    Beyond Supplements and Drugs: Live a "Good Cholesterol Lifestyle"

    No cholesterol-lowering program would be complete without a discussion of diet. Instead of dire warnings and restrictive regimes that drastically limit fat intake, Dr. Myatt puts her patients on The Super Fast Diet for cholesterol control. Her patients find this to be a rich, balanced, satisfying diet, and they are pleasantly surprised to find that not only do their cholesterol levels normalize in short order, but so does their weight. This nutrient-rich diet has people feeling better, looking better, and performing better, and their lab results are the proof of it’s effectiveness.

    Your Personal Cholesterol-Lowering Protocol

    For more information and dosage recommendations for natural cholesterol lowering remedies, please visit The Wellness Club website here: High Cholesterol Protocol
    http://www.DoctorMyatt.com/cholesterol.htm

    High cholesterol is a correctable dietary problem, not a statin drug deficiency! You can improve your cardiovascular risk far better by correcting underlying problems than by taking a liver-function-blocking drug. Why settle for a Band-Aid when a CURE is available?!

  • Stress: Warning Signs and Symptoms

    You’ve probably heard that excess stress is harmful, and information continues to stream from scientific studies about the precise effects of stress on our bodies. Here are the physical symptoms that can be caused by stress:

    • Dizziness or a general feeling of “being out of it”
    • General aches and pains
    • Grinding teeth, clenched jaw
    • Headaches
    • Indigestion
    • Increase in or loss of appetite
    • Muscle tension in neck, face or shoulders
    • Problems sleeping
    • Racing heart
    • Cold and sweaty palms
    • Tiredness, exhaustion
    • Trembling/shaking
    • Weight gain or loss
    • Upset stomach
    • Sexual difficulties

    Health effects of stress include:

    Forty-three percent of all adults suffer adverse health effects from stress. Seventy-five to 90% of all doctor’s office visits are for stress-related ailments and complaints.

    Stress is linked to six of the leading causes of death: heart disease, cancer, lung ailments, accidents, cirrhosis of the liver, and suicide.

    The Occupational Safety and Health Administration (OSHA) declared stress a hazard of the workplace. In terms of lost hours due to absenteeism, reduced productivity and workers’ compensation benefits, stress costs American industry more than $300 billion annually. The lifetime prevalence of an emotional disorder is more than 50%, often due to chronic, untreated stress reactions.

    More information can be found at The Wellness Club 
     

  • Big Fat Lies!

    Unlike carbohydrates, fats are an essential macronutrient and also the most misunderstood. The term “fat” actually refers to an entire family of fatty acids, each with very different biological functions. Only two fatty acids are essential, but the way in which all interact with each other plays an important role in how Essential Fatty Acids (EFA’s) are utilized. Deficiencies, excesses or relative deficiencies of EFA’s are now known to have serious health consequences. Because imbalanced dietary fats are strongly associated with many diseases, any diet aiming for optimal health must correct fat intake. A number of books address the importance of EFA’s, also called “Omegas,” but most contain elements of spurious science.

    The Myatt Diet dives deeper into the description and prescription for optimizing fat intake than any diet ever before, shattering some widely held but incorrect beliefs about certain fats and setting the record straight on others. Let’s look at some of the Big Fat Lies about fat that no other diet book has correctly explained, including:

    TRANS fats are the real villains among dietary fats, interfering with absorption of the Essential Fatty Acids, damaging cell membranes, elevating cholesterol level and altering the way normal cell membranes function. Trans fats are prevalent in the American diet, including many weight loss and “health” diets, but their intake should be drastically minimized for health reasons. In fact, the FDA recently passed a law requiring the amounts of trans fats to be listed separately on food nutrition labels.

    Saturated fats, the kind we get from eating steak, butter, cheese and eggs, are NOT unhealthy as they have been portrayed. In fact, they are so important that the human body produces them internally. Dietary saturated fat intake is not only safe but also necessary. Because “sat fats” do not compete with the EFA’s for absorption, do not turn “trans” or rancid, and maintain their chemical composition when heated, they are preferable for frying and high-heat cooking. The old belief that “saturated fats are unhealthy” was actually started many years ago based on some unscientific “science,” the edible oil industry in this country (who magnified the unsavory science in ads to discredit coconut oil and improve sales of domestic oils such as corn and cottonseed), and one wealthy businessman who mistakenly blamed his heart disease on saturated fats and paid for a huge, negative marketing campaign. Saturated fats are not villains, and some sat fats, such as coconut oil, have significant health benefits. (Coconut oil is antimicrobial, antiviral, is excellent for cooking for the reasons listed above, and can be used easily and directly as a calorie source, hence, it “burns” faster and “hotter” than many other types of calories).

    Further, the belief that monounsaturated oils (such as olive oil) are healthful and desirable is another Big Fat Lie. In truth, they are the white bread of the fatty acid family. Although better than Trans fats, “monos” serve no purpose in the body, are not essential, compete with the Essential Fatty Acids for utilization, and can turn into Trans fats with cooking.

    Omega-6 Fatty Acids are an Essential Fatty Acid (EFA) that needs to be balanced with it’s EFA partner, Omega-3, for optimal health. The American diet contains far too much of this essential fat and most people should not be taking supplements of O-6 oils.

    Omega-3 Fatty Acids, the other EFA, must partner with O-6 in a 4:1 to 10:1 ratio. Unfortunately, this EFA is exceptionally low in virtually every diet, from the Standard American Diet to Atkin’s to Pritiken, and especially the USDA food pyramid. No one has told us the truth, the whole truth, and nothing but the truth regarding optimal fat intake until now. On a truly healthful diet (primarily The Myatt Diet), you can have your steak (its “Omega Ratio” makes it far healthier than chicken), lavish butter on your broccoli and bathe your artichoke in mayonnaise, but that dainty olive oil vinaigrette that most would advise should be replaced by a healthier flax oil dressing.

    Heart Disease

    One of the best ways to help prevent and treat heart disease is to eat a diet low in trans fats and replace foods rich in trans and omega-6 fats with those that are rich in omega-3 fatty acids. EPA and DHA found in fish oil help reduce risk factors for heart disease including high cholesterol and high blood pressure. There is also strong evidence that these substances can help prevent and treat atherosclerosis by inhibiting the development of plaque and blood clots, each of which tends to clog arteries. Studies of heart attack survivors have found that daily omega-3 fatty acid supplements dramatically reduce the risk of death, subsequent heart attacks, and stroke. Similarly, people who eat an ALA-rich diet are less likely to suffer a fatal heart attack.

    Stroke

    Strong evidence from population-based studies suggests that omega-3 fatty acid intake (primarily from fish), helps protect against stroke caused by plaque buildup and blood clots in the arteries that lead to the brain. In fact, eating at least two servings of fish per week can reduce the risk of stroke by as much as 50%. However, people who eat more than three grams of omega-3 fatty acids per day (equivalent to 3 servings of fish per day) may be at an increased risk for hemorrhagic stroke, a potentially fatal type of stroke in which an artery in the brain leaks or ruptures. Keep in mind that 80% of strokes are due to blood clots, and only 20% are hemorrhagic. Further, it is weak blood vessels, not thin blood, that cause this rarer type of stroke. (Grape seed extract, available in supplement form, helps strengthen blood vessels among its other benefits).

    Weight Loss

    People who have trouble losing weight when dieting, including those who are resistant to weight loss on a ketogenic (Atkins’) diet, are likely to have a deficiency of Omega-3 fatty Acids OR an imbalanced ratio of O-6 to O-3. Improving this ratio of Essential Fatty Acid intake in the diet, without additional restriction on carbohydrates or calories, is often the key to unlocking this “metabolic resistance.”

    Arthritis

    Most clinical studies investigating the use of omega-3 fatty acid supplements for inflammatory joint conditions have focused almost entirely on rheumatoid arthritis. Several articles reviewing the research in this area conclude that omega-3 fatty acid supplements reduce tenderness in joints, decrease morning stiffness, and allow for a reduction in the amount of medication needed for people with rheumatoid arthritis.

    In addition, laboratory studies suggest that diets rich in omega-3 fatty acids (and low in omega-6 fatty acids) may benefit people with other inflammatory disorders, such as osteoarthritis. In fact, several test tube studies of cartilage-containing cells have found that omega-3 fatty acids decrease inflammation and reduce the activity of enzymes that destroy cartilage. In some participants, symptoms worsened before they improved.

    Depression

    People who do not get enough omega-3 fatty acids or do not maintain a healthy balance of omega-3 to omega-6 fatty acids in their diet may be at an increased risk for depression. The omega-3 fatty acids are important components of nerve cell membranes. They help nerve cells communicate with each other, which is an essential step in maintaining good mental health.

    Levels of omega-3 fatty acids were found to be measurably low and the ratio of omega-6 to omega-3 fatty acids were particularly high in a study of patients hospitalized for depression. In a study of people with depression, those who ate a healthy diet consisting of fatty fish two to three times per week for 5 years experienced a significant reduction in feelings of depression and hostility.

    Macular Degeneration

    A questionnaire administered to more than 3,000 people over the age of 49 found that those who consumed more fish in their diet were less likely to have macular degeneration (a serious age-related eye condition that can progress to blindness) than those who consumed less fish. Similarly, a study comparing 350 people with macular degeneration to 500 without found that those with a healthy dietary balance of omega-3 and omega-6 fatty acids and higher intake of fish in their diets were less likely to have this particular eye disorder. Another larger study confirms that EPA and DHA from fish, four or more times per week, may reduce the risk of developing macular degeneration.

    Colon Cancer

    Consuming significant amounts of foods rich in omega-3 fatty acids appears to reduce the risk of colorectal cancer. For example, Eskimos, who tend to follow a high fat diet but eat significant amounts of fish rich in omega-3 fatty acids, have a low rate of colorectal cancer. Animal studies and laboratory studies have found that omega-3 fatty acids prevent worsening of colon cancer while omega-6 fatty acids promote the growth of colon tumors. Daily consumption of EPA and DHA also appeared to slow or even reverse the progression of colon cancer in people with early stages of the disease.

    Breast Cancer

    Women who regularly consume foods rich in omega-3 fatty acids appear to be less likely to develop breast cancer. In addition, the risk of dying from breast cancer may be significantly less for those who eat large quantities of omega-3 from fish and brown kelp seaweed (common in Japan). This is particularly true among women who substitute fish for meat. The balance between omega-3 and omega-6 fatty acids appears to play an important role in the development and growth of breast cancer. The tissue levels of women with breast cancer are found to contain much lower levels of Omega-3 fatty acids than breast tissue from healthy controls.

    Some researchers hypothesize that omega-3 fatty acids in combination with other nutrients (namely, vitamin C, vitamin E, beta-carotene, selenium, and coenzyme Q10) may prove to be of particular value for preventing and treating breast cancer.

    Prostate Cancer

    Laboratory and animal studies indicate that omega-3 fatty acids (specifically, DHA and EPA) may inhibit the growth of prostate cancer. Similarly, population based studies of groups of men suggest that a low-fat diet with the addition of omega-3 fatty acids from fish or fish oil help prevent the development of prostate cancer. Like breast cancer, the balance of omega-3 to omega-6 fatty acids appears to be particularly important for reducing the risk of this condition.

    Other

    Preliminary evidence suggests that omega-3 fatty acids may also prove beneficial in protecting against infections, ulcers, migraine headaches, preterm labor, asthma, emphysema, psoriasis, glaucoma, Lyme disease, lupus, and panic attacks.

    Dietary Sources

    Fish oils and plant oils are the primary dietary source of omega-3 fatty acids. EPA and DHA are found in cold-water fish such as salmon, mackerel, halibut, sardines, and herring. ALA is found in flaxseeds & flaxseed oil. FISH and FLAX are the best sources. Other oils that contain significant amounts of Omega-3 are not recommended because they are also high in Omega-6. these include: canola (rapeseed) oil, soybeans, soybean oil, pumpkin seeds, pumpkin seed oil, purslane, walnuts, and walnut oil.

    Available Forms

    In addition to the dietary sources described, EPA and DHA can be taken in the form of fish oil Capsules. Flaxseed, flaxseed oil, and fish oil should be kept refrigerated. Whole flaxseeds should be ground within 1 week of use to ensure maximum potency.

    Be sure to buy omega-3 fatty acid supplements made by established companies who certify that their products are free of heavy metals such as mercury.

    How to Take It

    Flaxseed

    1 TBS. ground flax seed per day AND 1 TBS. flax oil per day OR 2 TBS. flax oil per day. (This corresponds to about 12 flax oil Capsules.)

    Flaxseed: 1 TBS two to three times per day or 2 to 4 tsp one time per day. Grind before eating and take with lots of water.

    EPA and DHA

    The adequate daily intake of EPA and DHA for adults should be at least 220 mg of each per day. Two to three servings of fatty fish per week (roughly 1,250 mg EPA and DHA per day) are generally recommended to treat certain health conditions.

    Fish oil supplements

    3,000 to 4,000 mg standardized fish oils per day. (This amount corresponds to roughly 2 to 3 servings of fatty fish per week.)

    Typically, a 1,000 mg fish oil Capsule has 180 mg EPA and 120 mg DHA

    ALA. Do NOT use cod liver oil on a regular basis, as it’s high vitamin A & D levels can become toxic. A physician should monitor high intakes of these fat-soluble vitamins. Regular EPA-containing fish oils do not contain vitamin A & D.

    Possible Interactions

    If you are currently being treated with any of the following medications, you should not use omega-3 fatty acid supplements without first talking to your healthcare provider.

    Blood-thinning Medications: Omega-3 fatty acids may increase the blood-thinning effects of aspirin or warfarin. While the combination of aspirin and omega-3 fatty acids may actually be helpful under certain circumstances (such as heart disease), they should only be taken together under the guidance and supervision of a knowledgeable nutritionally-oriented physician.

    Cyclosporine: Taking omega-3 fatty acids during cyclosporine therapy may reduce toxic side effects (such as high blood pressure and kidney damage) associated with this medication in transplant patients.

    Etretinate and Topical Steroids: The addition of omega-3 fatty acids (specifically EPA) to a drug regimen of etretinate and topical corticosteroids may improve symptoms of psoriasis.

    Cholesterol-lowering Medications: Following certain nutritional guidelines, including increasing the amount of omega-3 fatty acids in your diet and reducing the omega-6 to omega-3 ratio, may allow a group of cholesterol lowering medications known as “statins” (such as atorvastatin, lovastatin, and simvastatin) to work more effectively.

    Nonsteroidal Anti-inflammatory Drugs (NSAIDs): In an animal study, treatment with omega-3 fatty acids reduced the risk of ulcers from nonsteroidal anti-inflammatory drugs (NSAIDs). More research is needed to evaluate whether omega-3 fatty acids would have the same effects in people.
     

  • Hay Fever – Natural Remedies for Pollen and Seasonal Allergies

    Hay Fever – (Seasonal Allergies, Allergic Rhinitis)

    Natural Remedies for Pollen and Seasonal Allergies

    By Dr. Dana Myatt

    Hay Fever (also known as seasonal allergy) is caused by an over-reaction of the immune system to harmless airborne particles such as pollen.Symptoms of Hay fever can include any of the following:

    • stuffy or runny nose and nasal congestion
    • itchy, watery eyes
    • sneezing
    • coughing
    • post nasal drip
    • sinus pain or pressure
    • fatigue

    Hay fever is common in the Spring and Fall when airborne pollen counts are highest.Although hay fever effects some 40 million people annually, not everyone is susceptible to airborne pollens and particulates. So what makes a person vulnerable to seasonal allergies?

    Studies have shown that people with inhalant allergies are more likely to have food allergies. A hypo allergenic diet has has shown to help some people with asthma and allergic rhinitis. (1,2,3) Remember that avoidance of a food allergen, even if it does not improve hay fever, would be expected to improve over-all health.

    Pharmaceutical anti-allergy drugs often have undesirable side effects. So what can a person do to decrease hay fever symptoms without using drugs? Here are some of the best-proven natural remedies for alleviating seasonal allergies:

    1. Butterbur (Petasites hybridus): Butterbur has been shown in studies to be as effective as drugs at relieving symptoms of hay fever but without adverse side effects (4-8)One study compared Butterbur to the drug cetirizine (Zyrtec) and found that both relieved symptoms equally well. However, the drug was associated with a higher rate of adverse side effects including drowsiness.(4)

      A second study compared butterbur extract with fexofenadine (Allegra). Butterbur was just as effective as fexofenadine at relieving symptoms.(5)

      Because butterbur may contain pyrrolizidine alkaloids which can cause liver damage, use only extracts which have the pyrrolizidine alkaloids removed. This will be stated on the label.

      Symptom improvement is related to dosage, with higher doses producing more symptom relief. Suggested dose for best effect: 1-2 capsule, 3 times per day of an extract standardized to contain 7.5 mg of petasine per capsule. Look for formulas which state that they are pyrrolizidine alkaloid-free.(6)
       

    2. Grape seed extract — “nature’s anti-histamine.”Histamine is an irritating substance released from certain white blood cells (mast cells) in response to allergens. Anti-histamines block the histamine receptor and can improve symptoms of sneezing, itchy eyes and nose. Older antihistamines cause drowsiness, newer antihistamines are associated with heart complications. They are also expensive.

      Grape seed extract functions as an anti-histamine by stabilizing the mast cell, making it less ‘touchy” about releasing histamine. Grape seed extract has been shown to performs as a natural anti-histamine. (9-11)

      The “side effects” of grape seed extract are actually additional benefits, not unwanted side effects. Grape seed has been shown to improve chronic venous insufficiency (12-17), strengthen collagen and blood vessels(18-22),and help prevent cancer and heart disease through multiple mechanisms. (23-41) Grape seed extract is also a potent antioxidant. (27,33-34,42-47)

      Many people find grape seed extract effective for hayfever when taken 50-100mg, 3 times per day.
       

    3. Quercetin nasal spray. Quercetin is one of the most biologically active flavonoids, widely distributed in the plant kingdom in such species as oak trees (Quercus spp.), onions (Allium cepa) and tea (Camellia sinensis).Like grape seed extract, quercetin prevents acts as a natural anti-histamine by preventing the release of histamine from mast cells. (48) In fact, quercetin performs this function so well that it is used in medical experiments as a control substance for such activity (49-51). Quercetin is not well-absorbed orally, so higher doses must be taken, especially at the beginning of allergy treatment.

      A water-soluble form of quercetin, available as a nasal spray, is a safe and effective alternative to drug nasal sprays. The effects of quercetin nasal spray are felt within several minutes and last up to two hours. Pharmaceutical nasal sprays work by constricting blood vessels. They can have “addictive” effects on the nasal passages, and congestion becomes worse when they are discontinued. Quercetin does not create dependence or have rebound effects upon discontinuation. (52)

    References
    1. Speer F. Multiple food allergy. Ann Allerg 1975;34:71–6.
    2. Buczylko K, Kowalczyk J, Zeman K, et al. Allergy to food in children with pollinosis. Rocz Akad Med Bialymst 1995;40:568–72.
    3. Ogle KA, Bullock JD. Children with allergic rhinitis and/or bronchial asthma treated with elimination diet. Ann Allergy 1977;39:8–11.
    4.) Schapowal A, Petasites Study Group. Randomised controlled trial of butterbur and cetirizine for treating seasonal allergic rhinitis. BMJ 2002;324:144–6.
    5.) Lee DK, Gray RD, Robb FM, et al. A placebo-controlled evaluation of butterbur and fexofenadine on objective and subjective outcomes in perennial allergic rhinitis. Clin Exp Allergy 2004;34:646–9.
    6.) Schapowal A; Petasites Study Group. Butterbur Ze339 for the treatment of intermittent allergic rhinitis: dose-dependent efficacy in a prospective, randomized, double-blind, placebo-controlled study. Arch Otolaryngol Head Neck Surg. 2004 Dec;130(12):1381-6.
    7.) Lee DK, Carstairs IJ, Haggart K, Jackson CM, Currie GP, Lipworth BJ. Butterbur, a herbal remedy, attenuates adenosine monophosphate induced nasal responsiveness in seasonal allergic rhinitis. Clin Exp Allergy. 2003 Jul;33(7):882-6.
    8.) Käufeler R, Polasek W, Brattström A, Koetter U. Efficacy and safety of butterbur herbal extract Ze 339 in seasonal allergic rhinitis: postmarketing surveillance study.Adv Ther. 2006 Mar-Apr;23(2):373-84.
    9.) Iwasaki Y, Matsui T, Arakawa Y. The protective and hormonal effects of proanthocyanidin against gastric mucosal injury in Wistar rats. J Gastroenterol. 2004 Sep;39(9):831-7.
    10.) Kawai M, Hirano T, Higa S, Arimitsu J, Maruta M, Kuwahara Y, Ohkawara T, Hagihara K, Yamadori T, Shima Y, Ogata A, Kawase I, Tanaka T. Flavonoids and related compounds as anti-allergic substances. Allergol Int. 2007 Jun;56(2):113-23. Epub 2007 Mar 1.
    11.) Sharma SC, Sharma S, Gulati OP. Pycnogenol inhibits the release of histamine from mast cells. Phytother Res. 2003 Jan;17(1):66-9.
    12.) Dartenuc JY, Marache P, Choussat H. Resistance Capillaire en Geriatrie Etude d’un Microangioprotecteur. Bordeax Médical 1980;13:903–7 [in French].
    13.) Delacroix P. Etude en Double Avengle de l’Endotelon dans l’Insuffisance Veineuse Chronique. Therapeutique, la Revue de Medicine 1981;Sept 27–28:1793–1802 [in French].
    14.) Thebaut JF, Thebaut P, Vin F. Study of Endotelon in functional manifestations of peripheral venous insufficiency. Gazette Medicale 1985;92:96–100 [in French].
    15.) Cesarone MR, Belcaro G, Rohdewald P, Pellegrini L, Ledda A, Vinciguerra G, Ricci A, Gizzi G, Ippolito E, Fano F, Dugall M, Acerbi G, Cacchio M, Di Renzo A, Hosoi M, Stuard S, Corsi M. Rapid relief of signs/symptoms in chronic venous microangiopathy with pycnogenol: a prospective, controlled study. Angiology. 2006 Oct-Nov;57(5):569-76.
    16.) Cesarone MR, Belcaro G, Rohdewald P, Pellegrini L, Ledda A, Vinciguerra G, Ricci A, Gizzi G, Ippolito E, Fano F, Dugall M, Acerbi G, Cacchio M, Di Renzo A, Hosoi M, Stuard S, Corsi M.Comparison of Pycnogenol and Daflon in treating chronic venous insufficiency: a prospective, controlled study. Clin Appl Thromb Hemost. 2006 Apr;12(2):205-12.
    17.) Koch R. Comparative study of Venostasin and Pycnogenol in chronic venous insufficiency. Phytother Res. 2002 Mar;16 Suppl 1:S1-5.
    18.) Schlebusch H, Kern D. Stabilization of collagen by polyphenols. Angiologica 1972;9:248–56 [in German].
    19.) Monboisse J, Braquet P, Randoux A, Borel J. Non-enzymatic degradation of acid-soluble calf skin collagen by superoxide ion: protective effect of flavonoids. Biochem Pharmacol 1983;32:53–8.
    20.) Lagrue G, Olivier-Martin F, Grillot A. A study of the effects of procyanidol oligomers on capillary resistance in hypertension and in certain nephropathies. Sem Hop 1981;57:1399–401 [in French].
    21.) Galley P, Thiollet M. A double-blind, placebo-controlled trial of a new veno-active flavonoid fraction (S 5682) in the treatment of symptomatic capillary fragility. Int Angiol 1993;12:69–72.
    22.) Cho HS, Lee MH, Lee JW, No KO, Park SK, Lee HS, Kang S, Cho WG, Park HJ, Oh KW, Hong JT.Anti-wrinkling effects of the mixture of vitamin C, vitamin E, pycnogenol and evening primrose oil, and molecular mechanisms on hairless mouse skin caused by chronic ultraviolet B irradiation. Photodermatol Photoimmunol Photomed. 2007 Oct;23(5):155-62.
    23.) Buz’Zard AR, Lau BH.Pycnogenol reduces talc-induced neoplastic transformation in human ovarian cell cultures. Phytother Res. 2007 Jun;21(6):579-86.
    24.) Engelbrecht AM, Mattheyse M, Ellis B, Loos B, Thomas M, Smith R, Peters S, Smith C, Myburgh K. Proanthocyanidin from grape seeds inactivates the PI3-kinase/PKB pathway and induces apoptosis in a colon cancer cell line. Cancer Lett. 2007 Dec 8;258(1):144-53. Epub 2007 Oct 17.
    25.) Sharma G, Tyagi AK, Singh RP, Chan DC, Agarwal R.Synergistic anti-cancer effects of grape seed extract and conventional cytotoxic agent doxorubicin against human breast carcinoma cells.Breast Cancer Res Treat. 2004 May;85(1):1-12.
    26.) Bagchi D, Bagchi M, Stohs S, Ray SD, Sen CK, Preuss HG. Cellular protection with proanthocyanidins derived from grape seeds. Ann N Y Acad Sci. 2002 May;957:260-70.
    27.) Zhao J, Wang J, Chen Y, Agarwal R. Anti-tumor-promoting activity of a polyphenolic fraction isolated from grape seeds in the mouse skin two-stage initiation-promotion protocol and identification of procyanidin B5-3′-gallate as the most effective antioxidant constituent. Carcinogenesis. 1999 Sep;20(9):1737-45.
    28.) Hu H, Qin YM. Grape seed proanthocyanidin extract induced mitochondria-associated apoptosis in human acute myeloid leukaemia 14.3D10 cells. Chin Med J (Engl). 2006 Mar 5;119(5):417-21.
    29.) Zhang XY, Li WG, Wu YJ, Bai DC, Liu NF. Proanthocyanidin from grape seeds enhances doxorubicin-induced antitumor effect and reverses drug resistance in doxorubicin-resistant K562/DOX cells. Can J Physiol Pharmacol. 2005 Mar;83(3):309-18.
    30.) Zhang XY, Li WG, Wu YJ, Zheng TZ, Li W, Qu SY, Liu NF.Proanthocyanidin from grape seeds potentiates anti-tumor activity of doxorubicin via immunomodulatory mechanism.Int Immunopharmacol. 2005 Jul;5(7-8):1247-57. Epub 2005 Apr 7.
    31.) Agarwal C, Singh RP, Agarwal R. Grape seed extract induces apoptotic death of human prostate carcinoma DU145 cells via caspases activation accompanied by dissipation of mitochondrial membrane potential and cytochrome c release.Carcinogenesis. 2002 Nov;23(11):1869-76.
    32.) Kaur M, Agarwal R, Agarwal C. Grape seed extract induces anoikis and caspase-mediated apoptosis in human prostate carcinoma LNCaP cells: possible role of ataxia telangiectasia mutated-p53 activation. Mol Cancer Ther. 2006 May;5(5):1265-74.
    33.) Packer L, Rimbach G, Virgili F.Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol.Free Radic Biol Med. 1999 Sep;27(5-6):704-24.
    34.) Yang HM, Liao MF, Zhu SY, Liao MN, Rohdewald P. A randomised, double-blind, placebo-controlled trial on the effect of Pycnogenol on the climacteric syndrome in peri-menopausal women. Acta Obstet Gynecol Scand. 2007;86(8):978-85.
    36.) Mendes A, Desgranges C, Chèze C, Vercauteren J, Freslon JL. Vasorelaxant effects of grape polyphenols in rat isolated aorta. Possible involvement of a purinergic pathway. Fundam Clin Pharmacol. 2003 Dec;17(6):673-81.
    37.) Polagruto JA, Gross HB, Kamangar F, Kosuna K, Sun B, Fujii H, Keen CL, Hackman RM.Platelet reactivity in male smokers following the acute consumption of a flavanol-rich grapeseed extract.Platelet reactivity in male smokers following the acute consumption of a flavanol-rich grapeseed extract.
    38.) Holt RR, Actis-Goretta L, Momma TY, Keen CL. Dietary flavanols and platelet reactivity.J Cardiovasc Pharmacol. 2006;47 Suppl 2:S187-96; discussion S206-9.
    39.) Zhang FL, Gao HQ, Shen L. Inhibitory effect of GSPE on RAGE expression induced by advanced glycation end products in endothelial cells. J Cardiovasc Pharmacol. 2007 Oct;50(4):434-40.
    40.) Edirisinghe I, Burton-Freeman B, Tissa Kappagoda C. Mechanism of the endothelium-dependent relaxation evoked by a grape seed extract. Clin Sci (Lond). 2008 Feb;114(4):331-7.
    41.) Ray SD, Patel D, Wong V, Bagchi D. In vivo protection of dna damage associated apoptotic and necrotic cell deaths during acetaminophen-induced nephrotoxicity, amiodarone-induced lung toxicity and doxorubicin-induced cardiotoxicity by a novel IH636 grape seed proanthocyanidin extract.
    42.) Hosseini S, Pishnamazi S, Sadrzadeh SM, Farid F, Farid R, Watson RR. Pycnogenol((R)) in the Management of Asthma.J Med Food. 2001 Winter;4(4):201-209.
    43.) Carini M, Aldini G, Bombardelli E, Morazzoni P, Maffei Facino R.UVB-induced hemolysis of rat erythrocytes: protective effect of procyanidins from grape seeds. Life Sci. 2000 Sep 1;67(15):1799-814.
    44.) Lorenz P, Roychowdhury S, Engelmann M, Wolf G, Horn TF.Oxyresveratrol and resveratrol are potent antioxidants and free radical scavengers: effect on nitrosative and oxidative stress derived from microglial cells.Nitric Oxide. 2003 Sep;9(2):64-76.
    45.) Enginar H, Cemek M, Karaca T, Unak P.Effect of grape seed extract on lipid peroxidation, antioxidant activity and peripheral blood lymphocytes in rats exposed to x-radiation. Phytother Res. 2007 Nov;21(11):1029-35.
    46.) Dulundu E, Ozel Y, Topaloglu U, Toklu H, Ercan F, Gedik N, Sener G. Grape seed extract reduces oxidative stress and fibrosis in experimental biliary obstruction.J Gastroenterol Hepatol. 2007 Jun;22(6):885-92.
    47.) Du Y, Guo H, Lou H. Grape seed polyphenols protect cardiac cells from apoptosis via induction of endogenous antioxidant enzymes. J Agric Food Chem. 2007 Mar 7;55(5):1695-701. Epub 2007 Feb 13.
    48.) Leung, K.B., et.al. Differential effects of anti-allergic compounds on peritoneal mast cells of the rat, mouse and hamster. Agents Actions, 1984;14(3-4): 461-467.
    49.) Otsuka, H. et.al. Histochemical and functional characteristics of metachromatic cells in the nasal epithelium in allergic rhinitis: studies of nasal scrapings and their dispersed cells. J. Allergy Clin Immunol, 1995; 96(4):528-536.
    50.) Szabo, A. et.al. Mucosal permeability changes during intestinal reperfusion injury. The role of mast cells. Acta Chir Hung, 1997; 36(1-4):334-336.
    51.) Barrett, K.E. and D.D. Metcalfe. The histologic and functional characterization of enzymatically dispersed intestinal mast cells of nonhuman primates: effects of secretagogues and anti-allergic drugs on histamine secretion. J Immunol, 1985; 135(3): 2020-2026.
    52.) Remberg P, Björk L, Hedner T, Sterner O. Characteristics, clinical effect profile and tolerability of a nasal spray preparation of Artemisia abrotanum L. for allergic rhinitis.Phytomedicine. 2004 Jan;11(1):36-42.