Category: Fertility

  • I’m Pregnant! Now What?

    By Nurse Mark

     

    Many of our readers know that Dr. Myatt has been working closely with a an infertility specialist in New York city. Dr. Jeff Braverman is a Reproductive Immunologist and In Vitro Fertilization specialist who sought Dr. Myatt’s collaboration several years ago as he looked for ways to improve his already impressive success rate with the difficult cases.

    More recently, a prominent doctor in the San Francisco area, Dr. Christo Zouves, has been corresponding with Dr. Myatt and is recommending natural supplementation to his IVF and fertility enhancement patients as well.

    We are pleased to see increasing numbers of otherwise conventional allopathic specialists taking advantage of the powerful synergy that natural supplementation can bring to their treatment protocols – and we just love it when these women are able to tell us “I’m pregnant !”

    Along with becoming pregnant comes fear however: “What if I do something wrong and hurt or even lose my baby?”

    After all the hard work and often great expense of achieving conception, it’s no surprise that our new moms-to-be are leery of almost everything: there is so much misinformation out there and most of it consists of dire warnings about what can harm their precious new child.

    Indeed, if a mom-to be were to follow all the advice available to her from “friends,” family, acquaintances, and most especially the internet there would be very little she would be allowed to do for the next nine months but breathe – very carefully, of course!

    Everywhere she looks – anything she might wish to do – it all carries a risk; at least according to one self-proclaimed expert or another.

    It is especially so when it comes to vitamins, minerals, herbs, and other natural substances. There is a very large segment of the conventional, allopathic medical and nutritional community that is adamantly opposed to the use of anything non-prescription at any time, and the occasion of pregnancy gives them the opportunity to double down on their dire warnings about the evils of vitamins and herbs. Standard conventional advice with regards to natural supplements is always to “use with caution” and to immediately “discontinue all use” during pregnancy because “not enough is known about the safety of these substances during pregnancy”.

    Not enough is known by whom I wonder? By the conventional practitioners who had to turn simple, inexpensive fish oil into a hundreds of dollars per bottle Big Pharma prescription drug before cardiologists would prescribe it to their patients?

    Plenty is known about these natural supplements by the practitioners of natural medicine who rely on the experience and wisdom of thousands of years of use of these things and our readers and customers know that they can depend on Dr. Myatt and The Wellness Club to give them straight, well-researched answers to their questions.

    And so, Michele recently wrote to ask:

    I am interested in finding an alternative to Maxi Flavone during pregnancy since I’m concerned about using green tea (which I understand affects folic absorption) and ginkgo (which I understand may not good for pregnancy).

    If you recommend Maxi Flavone during pregnancy, can you give me some background?

     

    Maxi Flavone is one of our most requested supplements by our fertility patients. Dr. Myatt and Dr. Braverman worked extensively together to ensure that this would be an optimal broad-spectrum herbal antioxidant, anti-inflammatory, and TNF inhibiting formula that would be safe for use during pre and post conception. It has proved to be highly effective.

    However, I had a niggle about Michele’s question – I remembered hearing something about this a number of years ago, so I set about refreshing my memory. Here’s what I found:

    The caution with green tea centers around the ability of green tea to block the absorption of folate / folic acid – which of course is essential to fetal development.

    More specifically, it is the tannins in green tea that have this blocking effect.

    Those same tannins are also found in black tea, and  wine (horrors – not wine!). Nuts that can be consumed raw, such as hazelnuts, walnuts, and pecans, contain high amounts of tannins. Almonds have a lower content but it’s there. Herbs and spices such as Cloves, tarragon, cumin, thyme, vanilla, and cinnamon, and most legumes contain tannins. In other words, tannins are ubiquitous.

    It appears that massive  amounts of tea or other tannin-containing substances must be consumed, and consumed at the same time as folate-containing foods for this effect to be problematic or even apparent. According to an article fro 2009 published in the Journal of Physiologic Pharmacology: (1)

    Greeen tea extracts lower serum folates in rats at very high dietary concentrations only and do not affect plasma folates in a human pilot study.

     

    The worry about Ginkgo relates to single study / report that suggested that women who take ginkgo during pregnancy may be putting their fetuses at risk of abnormal development and warned that all pregnant women should avoid using ginkgo.

    It turns out that the authors of the study claimed to have found excessive colchicine levels in the blood of the women studied, and inferred that the ginkgo must have been adulterated with colchicine to cause this.

    It appears that the “researchers” fell victim to a basic chemistry mis-identification error because Ginkgo leaves contain a naturally occurring, nontoxic substance that is almost identical in structure to colchicine. The researchers who published the original report did not perform the test needed to differentiate these two compounds even though the blood levels of “colchicine” they claimed to have found should have set off alarms for them. If it really were colchicine these would be quite toxic levels and the women would have been very sick indeed. In other words, this was a seriously flawed study.

    Here is the original (flawed) study: http://www.ncbi.nlm.nih.gov/pubmed/11559040

    Bastyr University published and article explaining the faults and flaws of the study in detail: http://www.bastyrcenter.org/content/view/610/

    The Council For Responsible Nutrition issued a report refuting the claims of the study: http://www.crnusa.org/Shellnr082901gingko.html

    And other industry bodies have also weighed in with their rebuttals, such as The American Botanical Council http://cms.herbalgram.org/herbclip/pdfs/100511-211.pdf.

    So, the bottom line:

    There is no solid evidence that either green tea or ginko (when used sensibly) have a negative effect on fetal development or pregnancy.

    “All things in moderation!”

    And Michele is right – she knows that it’s possible, even likely, that the stressors that were causing her to experience inflammation and high TNF levels have not suddenly disappeared now that she is pregnant. So why discontinue a supplement that has been helping to keep inflammation and THF levels under control?

    There is one caution that may apply – ginko may have a mild antiplatelet effect and so there have been cautions to be careful with its use around the time of delivery – in order to minimize any risk of prolonged bleeding – according to an article in the Canadian Journal of  Clinical Pharmacology from  2006: (2)

    Ginkgo should be used with caution during pregnancy, particularly around labour where its anti-platelet properties could prolong bleeding time.

     

    These “anti-platelet” concerns could indeed be real, especially to a woman who is Vitamin K deficient – so, the solution? Ensure that Vitamin K levels are optimized by either enjoying a diet rich in Vitamin K containing foods or by supplementing to make up any shortfall. There is no “hyper coagulability”  associated with even high doses of Vitamin K and Vitamin K is important to fetal development.

     

    References:

     

    1.) http://www.ncbi.nlm.nih.gov/pubmed/?term=19826188

    J Physiol Pharmacol. 2009 Sep;60(3):103-8.

    Greeen tea extracts lower serum folates in rats at very high dietary concentrations only and do not affect plasma folates in a human pilot study.

    Augustin K, Frank J, Augustin S, Langguth P, Ohrvik V, Witthoft CM, Rimbach G, Wolffram S.

    Abstract

    Green tea catechins (GTC) have been shown to inhibit the activities of enzymes involved in folate uptake. Hence, regular green tea drinkers may be at risk of impaired folate status. The present experiments aimed at studying the impact of dietary GTC on folate concentrations and metabolism. In a human pilot study (parallel design) healthy men consumed for 3 weeks 6 capsules (approximately 670 mg GTC) per day (2 capsules with each principal meal) containing aqueous extracts of the leaves of Camellia sinensis (n=17) or placebo (n=16). No differences in plasma folate concentrations were observed between treatments. We further fed groups of 10 male rats diets fortified with 0, 0.05, 0.5, 1, or 5 g GTC/kg for 6 weeks. Only at the highest intake, GTC significantly decreased serum 5-methyl-tetrahydrofolate concentrations in rats, while mRNA concentrations of reduced folate carrier, proton-coupled folate transporter/heme carrier protein 1, and dihydrofolate reductase (DHFR) remained unchanged in intestinal mucosa. Using an in vitro enzyme activity assay, we observed a time- and dose-dependent inhibition of DHFR activity by epigallocatechin gallate and a green tea extract. Our data suggest that regular green tea consumption is unlikely to impair folate status in healthy males, despite the DHFR inhibitory activity of GTC.

     

    2.) Can J Clin Pharmacol. 2006 Fall;13(3):e277-84. Epub 2006 Nov 3.

    Safety and efficacy of ginkgo (Ginkgo biloba) during pregnancy and lactation.

    Dugoua JJ1, Mills E, Perri D, Koren G.

    CONCLUSIONS:

    Ginkgo should be used with caution during pregnancy, particularly around labour where its anti-platelet properties could prolong bleeding time. During lactation the safety of ginkgo leaf is unknown and should be avoided until high quality human studies are conducted to prove its safety.

    PMID: 17085776 [PubMed – indexed for MEDLINE]

  • An Exciting New Fertility Treatment

    Myo-inositol in the Treatment of PCOS and Non-PCOS Infertility

     

    By Dr. Dana Myatt

     

    Inositol is part of the vitamin B complex. It occurs as 9 different isomers, but only two of these are of interest in fertility: myo-inositol (MYO) and d-chiro-inositol (DCI)

    Both MYO and DCI have been studied and found useful in the treatment of PCOS (PolyCystic Ovary Syndrome). (1-14)

    However, only MI has been show to be present in follicular fluid and only MI was able to improve oocyte and embryo quality(1,2,9,12,15), ovulation induction (6-8,10-11) and hormone balance. (3-5,13)

    DCI does not have even remotely as much research behind it as MYO. (16)

    Therefor, for fertility issues with or without PCOS, I recommend the myo-inositol form.

    Please note that some of these studies used melatonin in combination with myo-inositol (2,11-12). Melatonin alone has also been studied and found useful for improving egg quality. (17-18)

    Myo-inositol may also improve other associated risks of PCOS (such as high triglycerides and blood sugars) with or without an effect on egg quality. (3,5,7)

    Most forms of inositol available in health food stores are probably the myo-inositol form. However, many products do not specify this on the label. I would always want to verify the actual form with the manufacturer before using.

    A product called “Pregnitude” is available, containing myo-inositol plus folic acid. Several studies used myo-inositol with folic acid and found improved egg quality in PCOS. (9,11)  All pre-pregnant women should already be getting folic acid from their multiple because of it’s importance in preventing spina bifida. This makes the “magic” in Pregnitude the myo-inositol. Pregnitude is individually packaged by 2 gram serving, which is convenient, but the price is double what what most myo-inositol powders are.

    Daily dose of myo-inositol for improving egg quality is 2-4 grams per day. This can be taken as 2 grams, once or twice daily.

    Myo-inositol product has a mild sweet taste and can be taken in water, smoothie, Super Shake — whatever makes it easiest.

    Egg Quality Protocol, Especially for PCOS Patients (Dr. Myatt’s recommendation based on the studies)

    1. myo-inositol: 2-4 grams per day
    2. melatonin: 3mg per day (take this at bedtime)
    3. folic acid: 400mcg (this amount or more should already be in a good multi-vitamin)

     

    [Nurse Mark comment: Any woman seeking to improve or enhance fertility should be using a good quality Optimal Dose multivitamin – we recommend Maxi Multi of course – but for those who want to shop around for something else, please use the ingredient list on the Maxi Multi page as a reference for what an Optimal Dose multivitamin should contain.]

     

    References
    1.) Ciotta L, Stracquadanio M, Pagano I, Carbonaro A, Palumbo M, Gulino F. Effects of myo-inositol supplementation on oocyte’s quality in PCOS patients: a double blind trial. Eur Rev Med Pharmacol Sci. 2011 May;15(5):509-14. [##myo for PCOS##]
    2.) Carlomagno G, Nordio M, Chiu TT, Unfer V. Eur J Obstet Gynecol Reprod Biol. 2011 Dec;159(2):267-72. Epub 2011 Aug 10.
    Contribution of myo-inositol and melatonin to human reproduction. http://www.ncbi.nlm.nih.gov/pubmed/21835536 [###myo and melatonin; egg quality##]
    3.) Costantino D, Minozzi G, Minozzi E, Guaraldi C. Metabolic and hormonal effects of myo-inositol in women with polycystic ovary syndrome: a double-blind trial. Eur Rev Med Pharmacol Sci. 2009 Mar-Apr;13(2):105-10.  {## myo for PCOS; hormones and metabolic factors##]
    4.) Donà G, Sabbadin C, Fiore C, Bragadin M, Giorgino FL, Ragazzi E, Clari G, Bordin L, Armanini D. Inositol administration reduces oxidative stress in erythrocytes of patients with polycystic ovary syndrome.Eur J Endocrinol. 2012 Apr;166(4):703-10. Epub 2012 Jan 5. [##MYO improves oxidative stress (decreases oxidative species), improves hormones in PCOS##]
    5.) Genazzani AD, Lanzoni C, Ricchieri F, Jasonni VM. Myo-inositol administration positively affects hyperinsulinemia and hormonal parameters in overweight patients with polycystic ovary syndrome.Gynecol Endocrinol. 2008 Mar;24(3):139-44.[##MYO; menstrual cycle improvements; better non-fertility numbers; 2 grams per day##]
    6.) Gerli S, Mignosa M, Di Renzo GC. Effects of inositol on ovarian function and metabolic factors in women with PCOS: a randomized double blind placebo-controlled trial. Eur Rev Med Pharmacol Sci. 2003 Nov-Dec;7(6):151-9. [##myo, PCOS, ovulation induction##]
    7.) Gerli S, Papaleo E, Ferrari A, Di Renzo GC. Randomized, double blind placebo-controlled trial: effects of myo-inositol on ovarian function and metabolic factors in women with PCOS. Eur Rev Med Pharmacol Sci. 2007 Sep-Oct;11(5):347-54. [## MYO, PCOS, improved ovulation, improved non-fertility peramiters (including weight loss)}
    8.) Morgante G, Orvieto R, Di Sabatino A, Musacchio MC, De Leo V. The role of inositol supplementation in patients with polycystic ovary syndrome, with insulin resistance, undergoing the low-dose gonadotropin ovulation induction regimen.Fertil Steril. 2011 Jun 30;95(8):2642-4. Epub 2011 Feb 5. [myo, PCOS, ovulation induction##]
    9.) Papaleo E, Unfer V, Baillargeon JP, Fusi F, Occhi F, De Santis L. Fertil Steril. 2009 May;91(5):1750-4. Epub 2008 May 7. Myo-inositol may improve oocyte quality in intracytoplasmic sperm injection cycles. A prospective, controlled, randomized trial. [##myo+ folic acid for egg quality in PCOS##]
    10.) Papaleo E, Unfer V, Baillargeon JP, De Santis L, Fusi F, Brigante C, Marelli G, Cino I, Redaelli A, Ferrari A. Myo-inositol in patients with polycystic ovary syndrome: a novel method for ovulation induction.Gynecol Endocrinol. 2007 Dec;23(12):700-3. Epub 2007 Oct 10. [##myo for ovulation in PCOS##]
    11.) Rizzo P, Raffone E, Benedetto V. Effect of the treatment with myo-inositol plus folic acid plus melatonin in comparison with a treatment with myo-inositol plus folic acid on oocyte quality and pregnancy outcome in IVF cycles. A prospective, clinical trial. Eur Rev Med Pharmacol Sci. 2010 Jun;14(6):555-61. [##myo+folic acid+melatonin##]
    12.) Unfer V, Raffone E, Rizzo P, Buffo S. Gynecol Endocrinol. 2011 Nov;27(11):857-61. Epub 2011 Apr 5. Effect of a supplementation with myo-inositol plus melatonin on oocyte quality in women who failed to conceive in previous in vitro fertilization cycles for poor oocyte quality: a prospective, longitudinal, cohort study. http://www.ncbi.nlm.nih.gov/pubmed/21463230  [##myo and melatonin##]
    13.) Unfer V, Carlomagno G, Dante G, Facchinetti F. Effects of myo-inositol in women with PCOS: a systematic review of randomized controlled trials. Gynecol Endocrinol. 2012 Jul;28(7):509-15. doi: 10.3109/09513590.2011.650660. Epub 2012 Feb 1. {##myo and improved ovarian function##]
    14.) Nestler JE, Jakubowicz DJ, Reamer P, Gunn RD, Allan G. Ovulatory and metabolic effects of D-chiro-inositol in the polycystic ovary syndrome. N Engl J Med. 1999 Apr 29;340(17):1314-20.[##DCI for PCO##]
    15.) Galletta M, Grasso S, Vaiarelli A, Roseff SJ. Bye-bye chiro-inositol – myo-inositol: true progress in the treatment of polycystic ovary syndrome and ovulation induction. Eur Rev Med Pharmacol Sci. 2011 Oct;15(10):1212-4. {####myo for egg quality, not dci)
    16.) Galazis N, Galazi M, Atiomo W. D-Chiro-inositol and its significance in polycystic ovary syndrome: a systematic review.Gynecol Endocrinol. 2011 Apr;27(4):256-62. Epub 2010 Dec 10.[##DCI not much research##]
    17.) Batioglu AS, Sahin U, Gürlek B, Oztürk N, Unsal E. The efficacy of melatonin administration on oocyte quality. Gynecol Endocrinol. 2012 Feb;28(2):91-3. Epub 2011 Jul 20. [##melatonin##]
    18.) Tamura H, Takasaki A, Miwa I, Taniguchi K, Maekawa R, Asada H, Taketani T, Matsuoka A, Yamagata Y, Shimamura K, Morioka H, Ishikawa H, Reiter RJ, Sugino N. Oxidative stress impairs oocyte quality and melatonin protects oocytes from free radical damage and improves fertilization rate. J Pineal Res. 2008 Apr;44(3):280-7.
    [##melatonin##]

  • Vegetarian And Fertile – Is It Possible?

    By Nurse Mark

     

    Is It Possible To Conceive And Carry To Term And Produce A Healthy Child While Following A Vegetarian Diet?

     

    Vegetarianism means different things to different people, and there are almost as many reasons given for the decision to follow a vegetarian diet as there are vegetarians to give them. Some of the more common reasons are:

    • Health (32%)
    • Because of chemicals and hormones in meat products (15%)
    • Don’t like the taste of meat (13%)
    • Love of animals (11%)
    • Animal rights (10%)
    • Religious reasons (6%)
    • Concern for the planet (4%)
    • To lose weight (3%)
    • To reduce hunger and famine worldwide (1%)

    (From a survey reported in “TIME Magazine: Veggie Tales”. Time. 2002-07-07)

    Before going any further, please let me assure all of the proselytizing, evangelical vegetarians and vegans (who are going to bury my email inbox anyway in letters filled with testimonial tributes to their dietary choices and demands that I read their favorite pro-vegetarian / anti animal protein study or article) – I am not going to tell anyone to not be a vegetarian or a vegan. I am simply going to present some information regarding nutrition as it pertains to vegetarian and vegan diets.

    How widespread and popular is the vegetarian diet?

    A 2008 study, commissioned by Vegetarian Times, claims that 3.2 percent of U.S. adults, or 7.3 million people, follow a vegetarian-based diet and that 1 million of those are vegans, who consume no animal products at all.

    The study further states that 10 percent of U.S., adults, or 22.8 million people, say they largely follow a vegetarian-inclined diet but fails to define what is meant by “largely follow” or “vegetarian-inclined.” Does this mean that they go meatless one day a week? Eat chicken but not beef? Usually have a salad with their steak dinner? Eat eggs but not ham for breakfast? The report doesn’t say.

    Vegetarian for moral and other reasons?

    In the Time Magazine study, a combined 32% of respondents reported following some degree of vegetarian diet for reasons of conscience: moral (animal rights), religious, or environmental beliefs. Such reasoning, like any firmly-held moral or religious conviction, cannot be argued with.

    Another 13% say they don’t care for the taste of meat. Does this mean that they eat eggs or cheese or whey protein? Is it only beef that they dislike, or pork, or lamb? Is fish or shrimp acceptable? All have very different tastes and textures which can be further modified by cooking technique and healthful spices…

    The concern expressed by some 15% regarding chemicals and hormones in meat products is certainly well-founded, but not impossible to address – certified all-organic, range fed, cage-free, free range, antibiotic and hormone free meats are increasingly available.

    The adoption of a vegetarian diet for weight loss is sometimes given (3% of respondents) and would seem to be an acknowledgement that the vegetarian diet is somehow lacking in nutrient density in order that it could result in weight loss. Since the typical vegetarian diet tends to be a high carbohydrate, limited protein, low fat diet it would need to be carefully restricted in order for weight loss to occur.

    That leaves vegetarian dieting for health reasons…

    32% of those questioned in the Time Magazine study claimed that “health reasons’ were what motivated their decision to adopt a vegetarian or vegan diet.

    There are a number of sources that promote vegetarian or vegan diets for health – perhaps some of the best known are “Eat More, Weigh Less” by Dr. Dean Ornish,  the nutritionally similar but not necessarily strictly vegetarian “Pritiken Principle” popularized by Nathan Pritiken, and perhaps the ultimate “indictment” of an animal protein based diet, “The China Study” written by Dr. T. Colin Campbell.

    On the plus side of the health equation, nutritionally well-planned vegetarian diets are usually rich in carbohydrates, omega-6 fatty acids, dietary fiber, carotenoids, folic acid, vitamin C, vitamin E, potassium and magnesium.

    If not carefully planned however, a vegetarian diet can be deficient in vitamin B12, calcium, omega-3 fatty acids, vitamin D, iron, zinc, riboflavin (vitamin B2), and iodine. Poorly planned vegan diets can be especially deficient in vitamin B12 and calcium.

    Of greater concern for vegetarians and especially vegans is getting adequate proteins (essential amino acids) in their diet. Though carefully chosen plant sources can supply adequate amounts of essential amino acids, the protein density of these foods is lower and thus more must be consumed.

    Cereals tend to be low in the essential amino acid lysine meaning that this must be made up with increased bean and soy products.

    Another important substance, Carnitine is biosynthesized from the amino acids lysine and methionine and may be lacking. In general, while anywhere from 20 to 200 mg are ingested per day by those on an omnivorous diet, people on a strict vegetarian or vegan diet may ingest as little as 1 mg per day.

    A similar-sounding but different amino acid, Carnosine is important to muscle and brain tissues. Vegetarian diets are thought to be lacking in carnosine though opinions differ as to the effect this deficiency has on vegetarians.

    Yet another organic acid, Taurine is found only in animal foods, and plays an vital role in brain development, blood pressure control, blood glucose regulation, as an antioxidant, and more. Taurine essential for cardiovascular function, and development and function of skeletal muscle, the retina and the central nervous system. Although the body can synthesize taurine from amino acids, many people — including pregnant or breast-feeding women — are unable to produce enough without a source from diet.

    Vegetarians who follow an ovo-lacto (eating eggs and dairy) eating plan are at much lower risk for many of these dietary deficiencies.

    While soy is an important protein source for vegetarians and vegans, increases in the amounts of soy consumed brings risks and problems since soy is a potent allergen for many people and can cause significant food intolerance, gut problems and inflammatory reactions. Soy is also a rich source of isoflavones called genistein and daidzein, which are a source of phytoestrogens that can potentially cause hormone disruptions and imbalances in both men and women.

    Soy is also a rich source of phytic acid.

    Phytic acid is also found within the hulls of nuts, seeds, and grains and has a strong binding affinity to important minerals, such as calcium, magnesium, iron, and zinc causing them to become non-absorbable in the intestines and actually chelating them. For this reason vegetarians and vegans who rely heavily on these food sources must be especially careful to supplement these minerals.

    Beans and legumes form an important part of most vegetarian / vegan diets. They can also cause significant digestive and immune distress in many people as they contain a substance called lectin.

    Foods containing lectin, such as beans, cereal grains, seeds, nuts, and potatoes, can be harmful when eaten in uncooked or improperly cooked form. Adverse effects may include nutritional deficiencies, and immune (allergic) reactions and associated inflammatory response. Lectins are thought to cause gastrointestinal distress through their interaction with (and damage to) the gut epithelial cells.

    Lectin may also cause leptin resistance which could be responsible for obesity in people who have high levels of leptin.

    Vegetarian / vegan diets are usually rich in Omega-6 fatty acids but can be deficient in Omega-3 fatty acids. This imbalance, if not carefully addressed, can lead to subtle inflammation. Omega-6 fatty acids are considered to be inflammatory, while Omega-3 fatty acids, as are found in fish oil, are considered to be anti-inflammatory.

    One possible source of anti-inflammatory Omega-3 essential fatty acids for vegetarians and vegans is walnuts. Another is flax seed and flax oil though the a-linoleic acid in flax requires additional conversion by the body to provide EPA (Eicosapentaenoic Acid) and DHA (Docosahexanoic Acid) – a conversion that many people find difficult to achieve. Fish oil is a far more reliable source of pre-formed EPA and DHA essential fatty acids.

    Since most vegetarian and vegan diets tend to be low fat diets as well deficiencies of fat soluble vitamins are a significant concern.

    Vitamin D,  acting as a hormone, increases the absorption of dietary calcium and phosphorus and works with a number of other vitamins, minerals, and hormones to promote bone mineralization.

    Research further suggests that vitamin D helps to maintain immune system health and helps regulate cell growth and differentiation.

    Obviously, vitamin D deficiencies can cause serious health problems, and those choosing vegetarian or vegan diets would do well to perform a Vitamin D test and to supplement with this important vitamin.

    Vitamin B12 deficiency is potentially very serious and can lead to megaloblastic anemia, nerve degeneration and irreversible neurological damage. Since vegetarians and especially vegans can be at high risk for B12 deficiency, most authorities recommend supplementation with this vitamin.

    Many cruciferous vegetables like broccoli, cauliflower, Brussel sprouts, kale, kohlrabi, mustard, turnips, rutabaga, cassava and cabbage, as well as soy products, pine nuts and peanuts, and millet are goitrogenic – meaning that when eaten in large quantities they can interfere with the normal functioning of the thyroid gland. Thyroid function testing may be well-advised for those who have been eating a lot of these foods or who suspect they may be experiencing decreased thyroid function.

    This is not intended to be an exhaustive list of the potential problems that can be encountered by those electing to follow a vegetarian / vegan diet – but rather a summary of the problems that we see most often here at the Wellness Club and amongst vegans and vegetarians who come to Dr. Myatt seeking dietary advice.

    Since dietary needs are increased in women who are pregnant, these problems and potential dietary deficiencies become that much more important – since a dietary deficiency in the mother will obviously be a dietary deficiency in the child growing in the womb.

    For those who are struggling to conceive, the subtle inflammations, dietary deficiencies and hormonal disruptions that can be caused by vegetarian and vegan diets can effectively sabotage all efforts to implant and maintain an embryo. Should a couple be successful in conceiving and carrying to term, they may find that maternal nutritional deficiencies have resulted in developmental problems or congenital flaws in the newborn.

    For this reason, Dr. Myatt is adamant that strict vegan diets are not appropriate for pre-conception or pregnant women, and that strict vegetarian diets are ill-advised unless very carefully monitored and supplemented.

    For women who wish to maintain some degree of vegetarian diet while improving health during pre-conception and maintaining maternal and fetal health during pregnancy, Dr. Myatt is available for consultation.

    Junk Food Vegetarians

    Another problem that we often see is with people who have adopted what they think is a vegetarian diet but who have actually only succeeded in removing essential nutrition from their diet. These are the people who have decided to eliminate animal-source protein and fats from their diet without replacing them with appropriate plant-based sources of these nutrients.

    We call these people “junk food vegetarians” because they substitute nutritionally empty junk foods for the previously healthy meats, eggs, and dairy that they have given up.

    There are many foods, especially convenience foods that qualify as “vegetarian” and potato chips, donuts, Kellogg’s “Pop Tarts”, any number of other nutritionally empty “foods” creep into the diet. Even those who manage to avoid the processed junk food trap often find themselves eating a diet of almost pure carbohydrates: a breakfast of oatmeal and bananas or cereal and fruit, a lunch of bread and peanut butter or a muffin, and then beans or corn or rice for supper’ Ensuring a varied and nutritionally complete vegetarian or vegan diet can be difficult with the hectic and harried schedules of most people.

    Yes, high fructose corn syrup is vegan – NO, it is not healthy! Peanut butter is not a complete protein, provides no Omega-3 fatty acids, and can harbor aflatoxin – a potent carcinogen. While there are plenty of chocolate and granola and fruit bars all marketed to vegetarians and vegans and claiming to be “healthy” they are often no better than a standard candy bar, containing the same high fructose corn syrups, cane sugar, hydrogenated vegetable oils and other ingredients.

     

    References and resources:

    http://en.wikipedia.org/wiki/Vegetarianism_by_country

    http://en.wikipedia.org/wiki/Vegetarian_nutrition

    Position of the American Dietetic Association and Dietitians of Canada: Vegetarian diets http://www.journals.elsevierhealth.com/periodicals/yjada/article/S0002-8223(03)00294-3/fulltext#section45

    The China Study: http://www.ncbi.nlm.nih.gov/pubmed/9860369

    Dr. Mercola critiques The China Study; http://articles.mercola.com/sites/articles/archive/2010/09/08/china-study.aspx

    Another well researched  critique of The China Study: http://rawfoodsos.com/the-china-study/

    A look at some of the pitfalls of vegetarian dieting by a former vegan: http://rawfoodsos.com/for-vegans/

    A maternal vegetarian diet in pregnancy is associated with hypospadias: http://onlinelibrary.wiley.com/doi/10.1046/j.1464-410x.2000.00436.x/full

    A comprehensive list of goitrogens: http://en.wikipedia.org/wiki/Goitrogen

  • Diets – What Is Your Diet?

    What’s In A Diet?

     

    A Multi-Installment Article By Nurse Mark

     

    For that matter, what is a “diet”?

    The word “diet” comes, via the Old French word diete and Latin word diaeta, from the Greek word díaita which translates to ‘mode of life’. So, in it’s most basic terms, your “diet” is just the way you live – including what you eat and how you eat it and what you do between the times that you eat.

    Some people just eat – they don’t think about it or worry about it, they just eat when they are hungry and stop eating when they are full (or when the food is gone.) They may be healthy, or not. They may be thin or normal weight or fat. For these people “diet” is not something that they associate with health or even think about – it’s just the way they are.

    At the other end of the spectrum are the people who are obsessed with food in one way or another: these are the people who are compulsive overeaters, or are anorexic, or bulimic or have other harmful food-related beliefs or practices. For these folks their way of life – their diet – is harmful to their health.

    The rest of us fall somewhere in between those two extremes.

    Most of us range anywhere from being vaguely aware that diet and health are connected to being actively involved in modifying and hopefully improving our health with conscious and deliberate efforts to change our food intake patterns.

    For most of us though the term “diet” doesn’t really mean “way of life” – it just means “way of eating.”

    There are also those for whom “diet” means their choices are influenced by their religious, spiritual or philosophical beliefs. Kosher, Halal, vegan, and others follow diets directed more by belief and philosophy than by science or biochemistry. There are even adherents of a dietary philosophy called Breatharianism who claim to be able to derive all the sustenance they need for life through the air they breathe and from sunlight. Not surprisingly, the followers of this rather extreme diet are prone to either “cheat” by eating solid food or to die of starvation – doing both with some regularity.

    Why do people diet?

    Let’s be honest – in today’s usage the term “diet” has come to have one common meaning. That is, to somehow reduce food intake to produce a loss of body fat.

    Oh sure, there are plenty of folks out there who have other food-related goals – athletes, celiacs, diabetics, people with food-related allergies, and so on. But most of us equate the term “diet” to “deprivation” and instinctively understand that “diet” means “things that you would like to eat but can’t because…(insert reason here: overweight, diabetic, allergic, etc.)”

    Therapeutic Diets

    Plenty of “dieters” follow regimens that restrict or promote certain foods or nutrients in order to achieve specific health goals. Some of these regimens are based on solid science and nutritional biochemistry, while others are based more on legend, rumor, marketing, Hollywood starlet testimonials, and so on.

    There are plenty of sound medical reasons for altering one’s food intake patterns. Some examples include (in no particular order):

    • Weight loss – the granddaddy of all reasons to alter food intake patterns, most popular weight loss diets involve portion control and / or calorie-counting (i.e. food deprivation,) consumption of “good carbs,” fat restriction, and other questionable dietary practices.
    • Control of epilepsy – a strategy dating back to the 19th century that was very successful in controlling epilepsy in children involved a very high fat, low carbohydrate, and lower protein intake – it is now very seldom used and is little-known in conventional medicine except as a curiosity.
    • Celiac disease – also known as sprue and gluten intolerance  is traditionally treated with a diet that avoids gluten, a common food substance that damages intestinal lining.
    • Hyperactivity – is often successfully treated with a diet that avoids sugars, synthetic food additives and colorants, and artificial sweeteners – though conventional medical and dietetic wisdom disputes the effectiveness of such diets.
    • Diabetes (type II) – while we find this to be an easily corrected condition, many diabetics prefer to follow the conventional recommendations of the American Diabetes Association which favors high carbohydrate / “low glycemic” foods, medication, and frequent blood sugar monitoring.
    • Weight gain / muscle gain – many diets are intended to reverse underweight from illness or to promote muscle mass increase in athletes. Most of these diets involve increasing the intake of simple carbohydrates which will result in an increase in fat mass (and a sparing of further loss of muscle mass) but do little to nourish muscle growth. Body-builders sometimes have some especially counter-productive dietary beliefs based more on locker-room legend than on sound biochemistry.
    • Cardiovascular health – conventional medical and dietetic wisdom has presented us with a plethora of “heart-healthy” diets – most of which rely on avoidance of fats, salt, animal protein, and sugar, while promoting the consumption of “healthy” and “low glycemic” carbohydrates, fruits, and vegetables. In our experience these diets are poorly effective and even harmful – but they do ensure the need for continued doctor visits and medication to control cholesterol and blood pressure.
    • Pregnancy – we’ve all heard that pregnant women are “eating for two” and while this is sometimes an excuse for overindulgence it really is true that without increased intake of fats, proteins, and essential vitamins and micronutrients, pregnancy can be difficult to achieve and even more difficult to maintain. Poor nutrition during pregnancy can and does produce sickly babies and sickly mothers – if it doesn’t cause miscarriage first.

    What is the “best” diet?

    That’s easy – the “best” diet is one that provides all the nutrients necessary to maintain or improve health, without providing anything that is not necessary.

    OK, maybe that’s not so easy after all.

    Let’s look at “nutrients” – what we need, and what we don’t, and how much we need. That might make things a little easier… And let’s try to keep this as simple as possible.

    In the most basic form, our dietary intake – what we eat – must provide our bodies with energy. Since we are warm-blooded creatures, that energy makes heat, and that heat is measured in “calories” (OK, some scientific types might measure it as B.T.U. or British Thermal Units – but most of us know calories.)

    There are three food groups that provide calories when eaten:

    • Essential Amino Acids, or Proteins
    • Essential Fatty Acids, or Fats
    • Carbohydrates (saccharides), from sugars and starches

    Alert readers will have noticed that two of those food groups have the term “essential” while the third does not.

    Amino Acids – Essential

    We are not able to synthesize (or make) a number of amino acids, and for this reason it is essential for us to obtain these building blocks of proteins from dietary intake.

    From Wikipedia:

    Most microorganisms and plants can biosynthesize all 20 standard amino acids, while animals (including humans) must obtain some of the amino acids from the diet. The amino acids that an organism cannot synthesize on its own are referred to as essential amino acids.

    and,

    An essential amino acid or indispensable amino acid is an amino acid that cannot be synthesized de novo by the organism (usually referring to humans), and therefore must be supplied in the diet.

    Without these Essential Amino Acid building blocks we cannot create (or maintain) muscle – and lest we forget, the heart is one of our more important muscles.

    According to the National Academy of Sciences, the average requirement for protein intake is:

    • adult women: 48 grams per day
    • adult men: 56 grams per day

    Pregnant women, children (up to age 18), endurance athletes and sick people have different (usually higher) requirements.

    Fats – Another Essential

    Like protein, fatty acids (the fancy biochemical way to just say “fats”) must be taken in through our diet – we must have them and we cannot “make” them.

    Again from Wikipedia:

    Only two EFAs are known for humans: alpha-linolenic acid (an omega-3 fatty acid) and linoleic acid (an omega-6 fatty acid).

    These two fatty acids, essential for our health, are absolutely vital for many of our metabolic processes, for the creation of hormones, for nerve function, and the life and health of cardiac cells. The balance between Omega-3 and Omega-6 fatty acids mediates such things as inflammation, mood, cellular signaling, and even activating or inhibiting transcription factors such as NF-κB in our DNA.

    How Much Do We Need?

    The National Academy of Science recommends a 4:1 to 10:1 (O-6:O-3) ratio. Population studies of long-lived people suggest that a 1:1 to 4:1 ratio is more in accord with healthful living. The Standard American Diet (SAD), typically contains a ratio of 20:1 or higher. The National Institutes of Health recommends that anywhere from from 1 to 12 or more grams of Omega-3 fatty acids be consumed daily depending on a person’s needs.

    Omega-3 Oils are derived primarily from fish oil and flax seeds. These essential fatty acids are anti-inflammatory and have a positive effect on cardiovascular disease, including high cholesterol and high blood pressure, allergic and inflammatory conditions (including psoriasis and eczema), autoimmune diseases, cancer, neurological disease, menopause, general health enhancement. Supplementation with Omega-3 Essential Fatty Acids can help “tip the scales” in favor of anti-inflammation.

    Omega-6 Oils are found in evening primrose, black current, borage and a number of vegetable oils. Although supplementation is popular, these oils are essential only in very small amounts. Excess Omega-6 oils increase arachadonic acid levels (an inflammatory substance).

    The Non-Essential Fatty Acid…

    Omega-9 Oils are found in olive, canola, and seed and nut oils. These oils are neutral, producing neither inflammation nor anti-inflammation. Unlike Omega-3 and Omega-6 fatty acids, Omega−9 fatty acids are not classed as essential fatty acids. This is both because they can be created by our body from unsaturated fat, and are therefore not essential in the diet, and because their lack of an n−6 double bond keeps them from participating in the reactions that form the eicosanoids.

    Carbohydrates – Not Essential!

    If you never ate another carbohydrate again – not a sugar or a starch, not cake nor cookies, or bread, pasta, potato, rice, or another baby carrot or banana ever, you would do just fine – maybe even better than “just fine”!

    According to Wikipedia:

    Carbohydrates are a common source of energy in living organisms; however, no carbohydrate is an essential nutrient in humans.

    And the National Academy of Sciences:

    The lower limit of dietary carbohydrate compatible with life apparently is zero, provided that adequate amounts of protein and fat are consumed.

    Our bodies are quite capable of meeting our minimal needs for glucose thanks to our liver and a process called “gluconeogenesis” – where our liver will happily make glucose (a carbohydrate) from fats and proteins.

    On the other hand, excessive carbohydrate metabolism causes a range of undesirable effects – from inflammation and generation of free radicals, to advanced glycosylated end products (A.G.E.S.), to hormonal disruptions, and more.

    So, in summary…

    • Everyone is on a “diet” of some sort
    • Some “diets” are followed for moral reasons, others for medical reasons.
    • The food intake of our “diet” provides us with energy – measured as “calories”
    • Of the three food types that we consume for energy, only two are “essential” to life

    In future articles we’ll look at some common physical conditions and how those conditions affect our dietary needs, and at some of the more trendy or popular diets with some thoughts on their strengths, weaknesses, and even dangers. We’ll also look at vitamins, minerals, and micronutrients to see how and where they fit into the dietary picture. Finally, we’ll look at how to put all this knowledge together and look at Nutrition Facts Boxes on foods so that we can make better dietary decisions.

     

    References:

    http://en.wikipedia.org/wiki/Carbohydrate

    http://www.ajcn.org/content/75/5/951.2.full

    http://www.nap.edu/catalog.php?record_id=10490

    http://en.wikipedia.org/wiki/Protein#Nutrition

    http://en.wikipedia.org/wiki/Essential_amino_acids

    http://en.wikipedia.org/wiki/Essential_fatty_acid

    http://www.nlm.nih.gov/medlineplus/druginfo/natural/993.html

  • Could This Supplement Be Causing My Symptoms?

    Could This Supplement Be Causing My Symptoms?

    By Nurse Mark

     

    Many of our regular readers and visitors to our website know that Dr. Myatt has been working closely with a highly-respected reproductive immunologist and infertility specialist in New York. Dr. Jeff Braverman contacted Dr. Myatt almost a year ago – he is a conventional (allopathic) infertility specialist, but he had heard of some successes with natural remedies and supplementation and was intrigued. He wanted to know more, to know how he could apply natural solutions to help his infertility patients conceive. He and Dr. Myatt have been collaborating since then, and Dr. Myatt has formulated some specialty products with Dr. Bravermans requirements and patients in mind. It has been a match made in heaven – Dr. Braverman has related his successes to us and it is clear that the combination of allopathic, high-tech, cutting edge fertility treatments and holistic, natural fertility-enhancing and health-improving strategies is a good mix indeed.

    Still, there arise questions and problems. This is not limited to infertility treatment; we get occasional calls or letters from customers with similar complaints that seem to have begun after newly starting other supplements.

    One problem we run into is that often people do not consider that there could be an interaction between drugs and supplements. If there is such a caution with a supplement you may be sure that Dr. Myatt has listed it on the web page that describes the supplement!

    Another problem is that people often don’t think to tell one doctor about the problems being treated by or the drugs that have been prescribed by another doctor. This is the age of specialization of course, and a patient may think what business is it of the infertility specialist to know about my stomach problems?

    Well, it can be of vital importance, as you will see from my answer to this person below. This highlights just why it is so very important, in this age of specialization, to have a doctor (like Dr. Myatt) who will oversee and coordinate your medical care, ensuring that nothing is missed – that even if the bone doctor doesn’t know or care what the kidney doctor is doing, and neither of them care what the allergy doctor has prescribed, someone will be there to make sure nothing is missed and that treatments for one condition do not adversely affect another condition.

     

    Here is a letter that recently arrived here:

    Good morning Dr. Myatt, hope all is well.

    Per the suggestion of Dr. Braverman, my husband has been on 2 Maxi Flavone’s a day since New Year’s Eve.  Do you know if the herbs in Maxi Flavone will or can disrupt an ulcer?  My husband was diagnosed with a stomach ulcer 3 months ago and currently on Nexium.  Since the past 4 days of him taking it, he wakes up with pretty bad stomach pains.  I’m not sure if the Maxi Flavone’s are irritating it again as he was feeling much better until he started taking these?

    Thank you,

    ~Andrea

    And here is my reply to Andrea:

    Hi Andrea,

    While it is extremely unlikely that Maxi Flavone is causing a return of your husbands stomach pains, it is impossible for us to say with absolute certainty since there is so much else about your husbands medical condition that we don’t know. Because of this, if he feels that the Maxi Flavone has caused him to experience stomach discomfort he should discontinue it until he has spoken with his own doctor and with Dr. Braverman about this.

    There are a great many things that can cause an exacerbation or return of stomach pain. Nexium is a drug that is approved for short-term use (4 to 8 weeks), generally for GERD and healing of erosive esophagitis. It is not intended for long-term use, though your husband’s doctor will most likely be very happy to continue to prescribe it indefinitely.

    Perhaps a better solution to your husbands complaints of stomach pain would be to correct the cause of the problem instead of masking the symptoms with a drug like Nexium. Does anyone really believe that GERD and ulcers are caused by a Nexium deficiency?

    Here is some very useful information that may be of interest to you and your husband both – Dr. Myatt and I have written extensively about this subject and have resolved (we can’t use the “cure” word – conventional medicine and Big Pharma have that one trademarked – only they are allowed to “cure”) many patients complaints of GERD and ulcers without resorting to the use of acid-blocking drugs.

    What’s Burning You? The REAL Cause of Heartburn, Indigestion and GERD (and How To Correct It) By Dr. Dana Myatt

    Would You Like Some Pneumonia With Your Acid Blocker Pill? By Nurse Mark

    Help – I’m Hooked On Acid Blocking Drugs! By Nurse Mark

    Again, there is nothing in Maxi Flavone that we know could cause an exacerbation (worsening) of gastric ulcer symptoms or pain – but if you or your husband feel that it may have contributed to the return of his stomach pain then you should stop using it until you have consulted with his gastroenterologist.

    If you wish to take a more holistic and natural approach to your husbands stomach / ulcer / digestive problems, Dr. Myatt is available for inexpensive Brief Phone Consultations and for more intensive and in-depth Alternative Medicine Consultations .

    One final note: Dr. Braverman recommended the Maxi Flavone for your husband in order to improve certain aspects of his nutritional status, thus enhancing his fertility too. When he is using acid blocking drugs such as Nexium his ability to properly digest and assimilate food and nutrients is being altered and his nutritional status is most likely significantly compromised. Improved nutritional status, that is having all the essential amino acids, essential fatty acids, vitamins, minerals, and micronutrients necessary for proper health and body function will be very important to your work with Dr. Braverman.

    Hope this helps,

    Cheers,

    Nurse Mark